It is estimated that one-third of the world's population is infected with tubercle bacillus and
the problem of tuberculosis (TB) has been intensified due to HIV pandemic providing a large …

The challenge of discovering new, urgently needed anti-TB drugs from natural sources
requires a truly interdisciplinary research. Cutting-edge mycobacteriology and innovative …

Macrophages (Mϕ) play a central role as effector cells in immunity to intracellular pathogens
such as Mycobacterium. Paradoxically, they also provide a habitat for intracellular bacterial …

Pathogenic mycobacteria resist lysosomal delivery after uptake into macrophages, allowing
them to survive intracellularly. We found that the eukaryotic-like serine/threonine protein …

Mycobacterium tuberculosis is an important pathogen of mammals that relies on 2-
hydroxyphenyloxazoline-containing siderophore molecules called mycobactins for the …

Vitamin D deficiency is associated with susceptibility to tuberculosis, and its biologically
active metabolite, 1α, 25 dihydroxyvitamin D 3 (1α, 25 (OH) 2 D 3), has pleiotropic immune …

Background Mycobacterium tuberculosis, the causative agent of tuberculosis, still represents
a major public health threat in many countries. Bioluminescence, the production of light by …

Objectives: The aim of this study was to identify a candidate drug for clinical development
from a previously synthesized combinatorial library based on the 1, 2-ethylenediamine …

Neutrophils contain antimicrobial peptides with antituberculous activity, but their contribution
to immune resistance to tuberculosis (TB) infection has not been previously investigated to …

Rationale: Vitamin D was used to treat tuberculosis (TB) in the preantibiotic era. Prospective
studies to evaluate the effect of vitamin D supplementation on antimycobacterial immunity …