Alternative splicing allows for the expression of multiple RNA and protein isoforms from one
gene, making it a major contributor to transcriptome and proteome diversification in …

Alternative splicing changes are frequently observed in cancer and are starting to be
recognized as important signatures for tumor progression and therapy. However, their …

Alternative splicing (AS) is an important event that contributes to posttranscriptional gene
regulation. This process leads to several mature transcript variants with diverse …

Splicing factor SRSF1 is upregulated in human breast tumors, and its overexpression
promotes transformation of mammary cells. Using RNA-seq, we identified SRSF1-regulated …

RNA-binding proteins (RBPs) are key players regulating RNA processing and are
associated with disorders ranging from cancer to neurodegeneration. Here, we present a …

Alternative splicing, a fundamental step in gene expression, is deregulated in many
diseases. Splicing factors (SFs), which regulate this process, are up-or down regulated or …

SRSF1 protein and U1 snRNPs are closely connected splicing factors. They both stimulate
exon inclusion, SRSF1 by binding to exonic splicing enhancer sequences (ESEs) and U1 …

The splicing factor SRSF1 promotes nonsense-mediated mRNA decay (NMD), a quality
control mechanism that degrades mRNAs with premature termination codons (PTCs). Here …

Vertebrates have evolved three paralogs, termed LUC7L, LUC7L2, and LUC7L3, of the
essential yeast U1 small nuclear RNA (snRNA)-associated splicing factor Luc7p. We …

The comprehensive but specific identification of RNA-binding proteins as well as the
discovery of RNA-associated protein functions remain major challenges in RNA biology …