Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor
The discovery of robust antidepressant actions exerted by the N-methyl-D-aspartate receptor
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …
(NMDAR) antagonist (R, S)-ketamine has been a crucial breakthrough in mood disorder …
[HTML][HTML] Effects of Withania somnifera (Ashwagandha) on stress and the stress-related neuropsychiatric disorders anxiety, depression, and insomnia
AB Speers, KA Cabey, A Soumyanath… - Current …, 2021 - ncbi.nlm.nih.gov
Background Withania somnifera (WS), also known as Ashwagandha, is commonly used in
Ayurveda and other traditional medicine systems. WS has seen an increase in worldwide …
Ayurveda and other traditional medicine systems. WS has seen an increase in worldwide …
The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …
burden of this debilitating disorder is anticipated to increase markedly over the coming …
Selecting an appropriate animal model of depression
Y Hao, H Ge, M Sun, Y Gao - International journal of molecular sciences, 2019 - mdpi.com
Depression has become one of the most severe psychiatric disorders and endangers the
health of living beings all over the world. In order to explore the molecular mechanism that …
health of living beings all over the world. In order to explore the molecular mechanism that …
A circadian rhythm-gated subcortical pathway for nighttime-light-induced depressive-like behaviors in mice
K An, H Zhao, Y Miao, Q Xu, YF Li, YQ Ma, YM Shi… - Nature …, 2020 - nature.com
Besides generating vision, light modulates various physiological functions, including mood.
While light therapy applied in the daytime is known to have anti-depressive properties …
While light therapy applied in the daytime is known to have anti-depressive properties …
Omega‐3 PUFA profoundly affect neural, physiological, and behavioural competences–Implications for systemic changes in trophic interactions
In recent decades, much conceptual thinking in trophic ecology has been guided by theories
of nutrient limitation and the flow of elements, such as carbon and nitrogen, within and …
of nutrient limitation and the flow of elements, such as carbon and nitrogen, within and …
A computational analysis of mouse behavior in the sucrose preference test
The sucrose preference test (SPT) measures the relative preference of sucrose over water to
assess hedonic behaviors in rodents. Yet, it remains uncertain to what extent the SPT …
assess hedonic behaviors in rodents. Yet, it remains uncertain to what extent the SPT …
High-fat diet induces depression-like phenotype via astrocyte-mediated hyperactivation of ventral hippocampal glutamatergic afferents to the nucleus accumbens
Comorbidity exists between metabolic disorders and depressive syndrome with unclear
mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet …
mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet …
Animal experimentation: implementation and application of the 3Rs
DI Lewis - Emerging Topics in Life Sciences, 2019 - portlandpress.com
Despite the development of powerful molecular biological techniques and technologies,
studies involving research animals remain a key component of discovery biology, and in the …
studies involving research animals remain a key component of discovery biology, and in the …
A hierarchical 3D-motion learning framework for animal spontaneous behavior mapping
Animal behavior usually has a hierarchical structure and dynamics. Therefore, to understand
how the neural system coordinates with behaviors, neuroscientists need a quantitative …
how the neural system coordinates with behaviors, neuroscientists need a quantitative …