Genetic contributions to suicidal thoughts and behaviors
Suicidal ideation, suicide attempt (SA) and suicide are significantly heritable phenotypes.
However, the extent to which these phenotypes share genetic architecture is unclear. This …
However, the extent to which these phenotypes share genetic architecture is unclear. This …
Biological factors underpinning suicidal behaviour: an update
Suicide, a global health burden, represents the 17th leading cause of death worldwide
(1.3%), but the 4th among young people aged between 15 and 29 years of age, according to …
(1.3%), but the 4th among young people aged between 15 and 29 years of age, according to …
[HTML][HTML] Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders, and known risk factors
Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …
which occur far more frequently, are a major source of disability and social and economic …
Genome-wide association study meta-analysis of suicide death and suicidal behavior
Suicide is a worldwide health crisis. We aimed to identify genetic risk variants associated
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …
with suicide death and suicidal behavior. Meta-analysis for suicide death was performed …
Identification of potential blood biomarkers associated with suicide in major depressive disorder
Suicides have increased to over 48,000 deaths yearly in the United States. Major depressive
disorder (MDD) is the most common diagnosis among suicides, and identifying those at the …
disorder (MDD) is the most common diagnosis among suicides, and identifying those at the …
Genome-wide association study of suicide death and polygenic prediction of clinical antecedents
Objective: Death by suicide is a highly preventable yet growing worldwide health crisis. To
date, there has been a lack of adequately powered genomic studies of suicide, with no …
date, there has been a lack of adequately powered genomic studies of suicide, with no …
Polygenic risk score as clinical utility in psychiatry: a clinical viewpoint
M Ikeda, T Saito, T Kanazawa, N Iwata - Journal of Human Genetics, 2021 - nature.com
Genome-wide association studies (GWASs) have detected many susceptible variants for
common diseases, including psychiatric disorders. However, because of the small effect size …
common diseases, including psychiatric disorders. However, because of the small effect size …
Genetics and epigenetics of self‐injurious thoughts and behaviors: Systematic review of the suicide literature and methodological considerations
Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent
need to advance research on its phenomenology and etiology. Epidemiological studies …
need to advance research on its phenomenology and etiology. Epidemiological studies …
Increased somatic mosaicism in autosomal and X chromosomes for suicide death
I Otsuka, S Uchiyama, T Shirai, X Liu… - Molecular …, 2024 - nature.com
Mosaic chromosomal alterations (mCAs) are classified as mosaic deletions (loss), copy-
neutral loss of heterozygosity (CN-LOH), and duplications (gain), attracting special attention …
neutral loss of heterozygosity (CN-LOH), and duplications (gain), attracting special attention …
[HTML][HTML] Sex-stratified gene-by-environment genome-wide interaction study of trauma, posttraumatic-stress, and suicidality
Epidemiologic studies recognize that trauma and posttraumatic stress are associated with
heightened suicidal behavior severity, yet examination of these associations from a genetic …
heightened suicidal behavior severity, yet examination of these associations from a genetic …