[HTML][HTML] Stabilization of enzymes via immobilization: Multipoint covalent attachment and other stabilization strategies

RC Rodrigues, Á Berenguer-Murcia… - Biotechnology …, 2021 - Elsevier
The use of enzymes in industrial processes requires the improvement of their features in
many instances. Enzyme immobilization, a requirement to facilitate the recovery and reuse …

Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

Constructing biocatalytic cascades: in vitro and in vivo approaches to de novo multi-enzyme pathways

SP France, LJ Hepworth, NJ Turner, SL Flitsch - Acs Catalysis, 2017 - ACS Publications
The combination of sequential biocatalytic reactions, via non-natural synthetic cascades, is a
rapidly developing field and leads to the generation of complex valuable chemicals from …

Chemoenzymatic dynamic kinetic resolution: a powerful tool for the preparation of enantiomerically pure alcohols and amines

O Verho, JE Bäckvall - Journal of the American Chemical …, 2015 - ACS Publications
Chemoenzymatic dynamic kinetic resolution (DKR) constitutes a convenient and efficient
method to access enantiomerically pure alcohol and amine derivatives. This Perspective …

Advances and applications of chiral resolution in pharmaceutical field

Y Teng, C Gu, Z Chen, H Jiang, Y Xiong, D Liu… - Chirality, 2022 - Wiley Online Library
The attention to chiral drugs has been raised to an unprecedented level as drug discovery
and development strategies grow rapidly. However, separation of enantiomers is still a huge …

Biocatalysis for synthesis of pharmaceuticals

RN Patel - Bioorganic & medicinal chemistry, 2018 - Elsevier
Chirality is a key factor in the safety and efficacy of many drug products and thus the
production of single enantiomers of drug intermediates and drugs has become important …

Enantioselective enzymatic desymmetrizations in organic synthesis

E García-Urdiales, I Alfonso, V Gotor - Chemical Reviews, 2005 - ACS Publications
During the recent past years, tremendous efforts have been made to establish
enantioselective routes for the preparation of enantiomerically pure compounds due to their …

Recent developments in dynamic kinetic resolution

H Pellissier - Tetrahedron, 2011 - Elsevier
This review updates the principal methods used to obtain dynamic kinetic resolution (DKR)
by either enzymatic or nonenzymatic methods, covering the literature from 2008 to the …

Stereodivergent protein engineering of a lipase to access all possible stereoisomers of chiral esters with two stereocenters

J Xu, Y Cen, W Singh, J Fan, L Wu, X Lin… - Journal of the …, 2019 - ACS Publications
Enzymatic stereodivergent synthesis to access all possible product stereoisomers bearing
multiple stereocenters is relatively undeveloped, although enzymes are being increasingly …

Lipases: Valuable catalysts for dynamic kinetic resolutions

AS de Miranda, LSM Miranda, ROMA de Souza - Biotechnology Advances, 2015 - Elsevier
Dynamic kinetic resolutions have proven to be a useful method for the preparation of
enantiopure compounds from racemates, leading to the formation of a single enantiomer in …