Deregulation of protein kinase activity has been shown to play a central role in the
pathogenesis of human cancer. The molecular pathogenesis of chronic myelogenous …

The application of block copolymer micelles (BCMs) in oncology has benefitted from
advances in polymer chemistry, drug formulation and delivery as well as in vitro and in vivo …

Background The aim of this study was to evaluate the ability of dual acridine
orange/ethidium bromide (AO/EB) staining to detect tumor cell apoptosis. According to …

Most solid malignancies display interstitial hypertension and a poor uptake of anticancer
drugs. Platelet-derived growth factor (PDGF) and the cognate tyrosine kinase receptors are …

The number of anticancer agents that fail in the clinic far outweighs those considered
effective, suggesting that the selection procedure for progression of molecules into the clinic …

While 3-D tissue models have received increasing attention over the past several decades
in the development of traditional anti-cancer therapies, their potential application for the …

The natural isoflavone genistein inhibits the growth of a number of tumour cell lines in vitro.
During investigations on the antiproliferative effects of genistein we observed that, with …

Tumors are complex systems consisting of heterogeneous cancer cells as well as normal
cells with each exhibiting unique drug sensitivity spectra. There have been many attempts to …

Anticancer compound screening on 2D cell cultures poorly predicts “in vivo” performance,
while conventional 3D culture systems are usually characterized by limited cell proliferation …

Chemotherapy of solid tumors is presently largely ineffective at dosage levels that are
compatible with survival of the patient. Here, it is argued that a condition of raised interstitial …