Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream
with Janus kinases (JAK) family protein and capable of integrating inputs from different …

Runt-related transcription factor 1 (RUNX1) is frequently involved in the progression of acute
leukemia. However, emerging and discoverable RUNX1 somatic mutations, RUNX1 …

Background Runt-related transcription factor 1 (RUNX1) plays the roles of an oncogene and
an anti-oncogene in epithelial tumours, and abnormally elevated RUNX1 has been …

The molecular mechanisms underlying the differentiation of interleukin 17–producing T
helper cells (TH-17 cells) are still poorly understood. Here we show that optimal transcription …

In Asia, the prevalence of Helicobacter pylori (H. pylori) infection varies markedly in different
countries. Higher prevalence rates are found in developing Asian countries while lower …

Purpose To evaluate frequency, biologic features, and clinical relevance of RUNX1
mutations in acute myeloid leukemia (AML). Patients and Methods Diagnostic samples from …

Monocytes are versatile cells that can express different functional programs in response to
microenvironmental signals. We show that primary blood monocytes secrete the CXCL12 …

Three fundamental issues in postgenomic biology are (i) how the amino acid sequence of a
given human protein predicates its structure, function, and regulation;(ii) how a protein is …

Analyses of 164 RUNX1 mutations (RUNX1 mut) in 147 of 449 patients (32.7%) with normal
karyotype or noncomplex chromosomal imbalances were performed. RUNX1 mut were most …

Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the
expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic …