In the three-dimensional (3D) tumor microenvironment, matrix stiffness is associated with the
regulation of tumor cells behaviors. In vitro tumor models with appropriate matrix stiffness …

The stiffness of tumors and their host tissues is much higher than most hydrogels, which are
conventionally used to study in vitro cancer progression. The tumoroid assay is an …

Abstract 3D laboratory models of cancer are designed to recapitulate the biochemical and
biophysical characteristics of the tumour microenvironment and aim to enable studies of …

Epidermal growth factor receptor 2 (HER2) is the second target molecule most commonly
used in breast cancer treatment. Both recurrence and metastasis are still deadly for HER2+ …

One of the major cancer types that have gained significant importance globally is the breast
cancer due to its socio-economic impact. Breast cancer research is an area of considerable …

Simple Summary Human breast cancers are not fully autonomous. They are dependent on
nutrients and growth-promoting signals provided by stromal cells. In order to instruct the …

Human breast tumors are not fully autonomous. They are dependent on nutrients and
growth-promoting signals provided by the supporting stromal cells. Within the tumor …

Detection of nuclei is an important step in phenotypic profiling of 1) histology sections
imaged in bright field; and 2) colony formation of the 3-D cell culture models that are imaged …

The acquisition of resistance to EGFR tyrosine kinase inhibitors (TKIs) remains a critical
problem in lung cancer clinic, but the underlying mechanisms have remained incompletely …

The interaction between extracellular matrix (ECM) and epithelial cells plays a key role in
lung development. Our studies found that mice with conditional integrin β 4 (ITGB4) …