The elongation stage of transcription by RNA polymerase II (RNA Pol II) is central to the
regulation of gene expression in response to developmental and environmental cues in …

A large body of work in the last four decades has revealed the key pillars of HIV-1
transcription control at the initiation and elongation steps. Here, I provide a recount of this …

In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase
progression and escape from immune surveillance. Here we show that MYC in PDAC cells …

The HIV-1 Tat protein hijacks the Super Elongation Complex (SEC) to stimulate viral
transcription and replication. However, the mechanisms underlying Tat activation and …

The persistence of HIV-1 in long-lived latent reservoirs during suppressive antiretroviral
therapy (ART) remains one of the principal barriers to a functional cure. Blocks to …

The release of paused RNA polymerase II (RNAPII) from promoter-proximal regions is tightly
controlled to ensure proper regulation of gene expression. The elongation factor PTEF-b is …

Within the first 15 minutes of infection, herpes simplex virus 1 immediate early proteins
repurpose cellular RNA polymerase (Pol II) for viral transcription. An important role of the …

Transcriptionally latent forms of replication-competent proviruses, present primarily in a
small subset of memory CD4+ T cells, pose the primary barrier to a cure for HIV-1 infection …

Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative
strategy for viral eradication is still needed. The cessation of ART results in rapid viral …

In the ongoing arms race between virus and host, fine-tuned gene expression plays a critical
role in antiviral signaling. However, viruses have evolved to disrupt this process and …