Activation and regulation of purinergic P2X receptor channels
Mammalian ATP-gated nonselective cation channels (P2XRs) can be composed of seven
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
possible subunits, denoted P2X1 to P2X7. Each subunit contains a large ectodomain, two …
Molecular and functional properties of P2X receptors—recent progress and persisting challenges
K Kaczmarek-Hájek, É Lörinczi, R Hausmann… - Purinergic …, 2012 - Springer
Abstract ATP-gated P2X receptors are trimeric ion channels that assemble as homo-or
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
heteromers from seven cloned subunits. Transcripts and/or proteins of P2X subunits have …
P2X4 receptor function in the nervous system and current breakthroughs in pharmacology
Adenosine 5′-triphosphate is a well-known extracellular signaling molecule and
neurotransmitter known to activate purinergic P2X receptors. Information has been …
neurotransmitter known to activate purinergic P2X receptors. Information has been …
P2X4 receptors mediate PGE2 release by tissue‐resident macrophages and initiate inflammatory pain
L Ulmann, H Hirbec, F Rassendren - The EMBO journal, 2010 - embopress.org
Prostaglandin E2 (PGE2) is a key mediator of inflammation and contributes to pain
hypersensitivity by promoting sensory neurons hyperexcitability. PGE2 synthesis results …
hypersensitivity by promoting sensory neurons hyperexcitability. PGE2 synthesis results …
Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain
One of the most significant advances in pain research is the realization that neurons are not
the only cell type involved in the etiology of chronic pain. This realization has caused a …
the only cell type involved in the etiology of chronic pain. This realization has caused a …
ATP-mediated signalling in the central synapses
U Lalo, Y Pankratov - Neuropharmacology, 2023 - Elsevier
ATP released from the synaptic terminals and astrocytes can activate neuronal P2 receptors
at a variety of locations across the CNS. Although the postsynaptic ATP-mediated signalling …
at a variety of locations across the CNS. Although the postsynaptic ATP-mediated signalling …
ATP receptors gate microglia signaling in neuropathic pain
Microglia were described by Pio del Rio-Hortega (1932) as being the 'third element'distinct
from neurons and astrocytes. Decades after this observation, the function and even the very …
from neurons and astrocytes. Decades after this observation, the function and even the very …
Altered hippocampal synaptic potentiation in P2X4 knock-out mice
JA Sim, S Chaumont, J Jo, L Ulmann… - Journal of …, 2006 - Soc Neuroscience
P2X4 purinergic receptors are calcium-permeable, ATP-activated ion channels. In the CA1
area of the hippocampus, they are located at the subsynaptic membrane somewhat …
area of the hippocampus, they are located at the subsynaptic membrane somewhat …
ATP P2X receptors downregulate AMPA receptor trafficking and postsynaptic efficacy in hippocampal neurons
Summary P2X receptors (P2XRs) are ATP-gated cation channels widely expressed in the
brain where they mediate action of extracellular ATP released by neurons or glia. Although …
brain where they mediate action of extracellular ATP released by neurons or glia. Although …
Molecular properties of P2X receptors
JA Roberts, C Vial, HR Digby, KC Agboh, H Wen… - Pflügers Archiv, 2006 - Springer
P2X receptors for adenosine tri-phosphate (ATP) are a distinct family of ligand-gated cation
channels with two transmembrane domains, intracellular amino and carboxy termini and a …
channels with two transmembrane domains, intracellular amino and carboxy termini and a …