Maternal-fetal inflammation in the placenta and the developmental origins of health and disease
JA Goldstein, K Gallagher, C Beck, R Kumar… - Frontiers in …, 2020 - frontiersin.org
Events in fetal life impact long-term health outcomes. The placenta is the first organ to form
and is the site of juxtaposition between the maternal and fetal circulations. Most diseases of …
and is the site of juxtaposition between the maternal and fetal circulations. Most diseases of …
Genetics and epigenetics in asthma
P Ntontsi, A Photiades, E Zervas, G Xanthou… - International journal of …, 2021 - mdpi.com
Asthma is one of the most common respiratory disease that affects both children and adults
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …
worldwide, with diverse phenotypes and underlying pathogenetic mechanisms poorly …
Global impact of unproductive splicing on human gene expression
Alternative splicing (AS) in human genes is widely viewed as a mechanism for enhancing
proteomic diversity. AS can also impact gene expression levels without increasing protein …
proteomic diversity. AS can also impact gene expression levels without increasing protein …
Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease
STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …
central role in the pathophysiology of allergic inflammation. We have identified 16 patients …
The genetics of asthma and the promise of genomics-guided drug target discovery
Asthma is an inflammatory airway disease that is estimated to affect 339 million people
globally. The symptoms of about 5–10% of patients with asthma are not adequately …
globally. The symptoms of about 5–10% of patients with asthma are not adequately …
The genetics of epilepsy
P Perucca, M Bahlo, SF Berkovic - Annual review of genomics …, 2020 - annualreviews.org
Epilepsy encompasses a group of heterogeneous brain diseases that affect more than 50
million people worldwide. Epilepsy may have discernible structural, infectious, metabolic …
million people worldwide. Epilepsy may have discernible structural, infectious, metabolic …
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
K Valette, Z Li, V Bon-Baret, A Chignon… - Communications …, 2021 - nature.com
To identify candidate causal genes of asthma, we performed a genome-wide association
study (GWAS) in UK Biobank on a broad asthma definition (n= 56,167 asthma cases and …
study (GWAS) in UK Biobank on a broad asthma definition (n= 56,167 asthma cases and …
Genome-wide analysis highlights contribution of immune system pathways to the genetic architecture of asthma
Asthma is a chronic and genetically complex respiratory disease that affects over 300 million
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …
people worldwide. Here, we report a genome-wide analysis for asthma using data from the …
Functions and regulation of T cell-derived interleukin-10
Abstract Interleukin (IL)-10 is an essential anti-inflammatory cytokine and functions as a
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
negative regulator of immune responses to microbial antigens. IL-10 is particularly important …
Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe
Ancient genomics can directly detect human genetic adaptation to environmental cues.
However, it remains unclear how pathogens have exerted selective pressures on human …
However, it remains unclear how pathogens have exerted selective pressures on human …