Once myocardium dies during a heart attack, it is replaced by scar tissue over the course of
several weeks. The size, location, composition, structure and mechanical properties of the …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Composed of type I and III collagens, the valve leaflets, chordae tendineae and collagen
matrix of the myocardium form a structural continuum. Synthesized by cardiac fibroblasts …

Increased activity of matrix metalloproteinases (MMPs) has been implicated in numerous
disease processes, including tumor growth and metastasis, arthritis, and periodontal …

In this study changes in the amount and distribution of types I and III collagen mRNA and
protein were investigated in the rat heart after induction of a left ventricular myocardial …

▪ Abstract Therapies for myocardial infarction have historically been developed by trial and
error, rather than from an understanding of the structure and function of the healing infarct …

Extracellular matrix (ECM) components play essential roles in development, remodeling,
and signaling in the cardiovascular system. They are also important in determining the …

▪ Abstract Computational models of the electrical and mechanical function of the heart are
reviewed. These models attempt to explain the integrated function of the heart in terms of …

Matrix metalloproteinases (MMPs) are traditionally known for their role in extracellular matrix
remodeling. Increasing evidence reveals several alternative substrates and novel biological …

Remodeling of the myocardium is the major mechanism for disability and death in prevalent
cardiovascular diseases such as hypertension, heart failure and myocardial infarction (MI). It …