New Findings• What is the central question of this study? In human arteries involved in the
regulation of muscle blood flow, there is a lack of data about whether acidosis alters …

The transcription factor HIF-1α has been identified as a key regulator in the cellular and
systemic response to hypoxia. Because hypoxia is frequently associated with acidosis, like …

Aims/hypothesis Despite advances in pharmacological treatments, diabetes with
hypertension continues to be a major public health problem with high morbidity and mortality …

Metabolic acidosis is associated with various clinical situations including diabetes mellitus
and renal diseases. The aim of this study was to investigate the effects of acidosis on the …

Objective: The objective of this study was to characterize the α 1-adrenoceptor (α 1-AR)
subtypes and evaluate the effect of acidosis on α 1-AR function and expression in goat …

Abstract aveolae appear in a multitude of processes encompassing growth regulation
andtrafficking. We demonstrate the abundant presence of ESA/reggie-1/flotillin-2, ATP …

The effects of acidosis were investigated on the resting and precontracted aortas from Wistar
and Wistar Kyoto (WKY) rats. Decrease in pH from 7.4 to 6.5, having no effect on the resting …

Aim: This study was conducted to investigate the mechanism of acidic pH‐induced
contraction (APIC) with regard to Ca2+ handling using isometric tension recording …

This study was performed to test the hypothesis that activation of protein kinase C (PKC) is a
mechanism underlying the acidic pH-induced contraction (APIC) in spontaneously …

Despite the discrepancies observed between data generated from humans and animals, it is
common practice to extrapolate data from animal models to humans. This chapter discusses …