Excitotoxicity is classically defined as the neuronal damage caused by the excessive
release of glutamate, and subsequent activation of excitatory plasma membrane receptors …

Non‐conventional N‐methyl‐d‐aspartate receptors (NMDARs) containing GluN3A subunits
have unique biophysical, signalling and localization properties within the NMDAR family …

Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin that supports
the survival, differentiation, and signaling of various neuronal populations. Although it has …

Activity-regulated cytoskeleton-associated protein (Arc) is one of the most important
regulators of cognitive functions in the brain regions. As a hub protein, Arc plays different …

Experience-and activity-dependent transcription is a candidate mechanism to mediate
development and refinement of specific cortical circuits. Here, we demonstrate that the …

As the global population ages, the need to prolong lifespan and healthspan becomes
increasingly imperative. Understanding the molecular determinants underlying cognitive …

Mutations in the activity-dependent transcription factor MEF2C have been associated with
several neuropsychiatric disorders. Among these, autism spectrum disorder (ASD)-related …

De novo protein synthesis is required for synapse modifications underlying stable memory
encoding. Yet neurons are highly compartmentalized cells and how protein synthesis can be …

Hypothalamic adult neurogenesis provides the basis for renewal of neurons involved in the
regulation of whole-body energy status. In addition to hormones, cytokines and growth …

The GluN3A subunit of N-methyl-D-aspartate receptors (NMDARs) plays an established role
in synapse development, but its contribution to neural circuits in the adult brain is less clear …