Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

The brain and the immune system are not fully formed at birth, but rather continue to mature
in response to the postnatal environment. The two-way interaction between the brain and …

Neurons in the developing brain undergo extensive structural refinement as nascent circuits
adopt their mature form. This physical transformation of neurons is facilitated by the …

Programmed cell death (PCD) plays a fundamental role in animal development and tissue
homeostasis. Abnormal regulation of this process is associated with a wide variety of human …

Neurons require trophic support during neural circuit formation; however, how the cellular
milieu contributes to neuronal survival remains unclear. We found that layer V cortical …

I outline how understanding the mechanism of behavioural plasticity is important for
predicting how organisms will respond to rapidly changing and novel environments. I define …

Over the past two decades it became evident that the immune system plays a central role in
modulating learning, memory and neural plasticity. Under normal quiescent conditions …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

Axonal and synaptic degeneration is a hallmark of peripheral neuropathy, brain injury, and
neurodegenerative disease. Axonal degeneration has been proposed to be mediated by an …

Microglia are the resident brain macrophages and they have been traditionally studied as
orchestrators of the brain inflammatory response during infections and disease. In addition …