Protein complexes composed of many subunits carry out most essential processes in cells
and, therefore, have become the focus of intense research. However, deciphering the …

The nucleoside analog remdesivir (RDV) is a Food and Drug Administration–approved
antiviral for treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control
this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS …

SARS-CoV-2 is the pathogen responsible for the COVID-19 pandemic. The SARS-CoV-2
papain-like cysteine protease (PLpro) has been implicated in playing important roles in virus …

Antiviral drugs for managing infections with human coronaviruses are not yet approved,
posing a serious challenge to current global efforts aimed at containing the outbreak of …

Remdesivir (GS-5734) is a 1′-cyano-substituted adenosine nucleotide analogue prodrug
that shows broad-spectrum antiviral activity against several RNA viruses. This compound is …

DNA methylation is an epigenetic modification that is generally associated with repression of
transcription initiation at CpG-island promoters. Here we argue that, on the basis of recent …

In most bacteria, cell division relies on the synthesis of new cell wall material by the
multiprotein divisome complex. Thus, at the core of the divisome are the transglycosylase …

Argonaute proteins lie at the heart of the RNA-induced silencing complex (RISC), wherein
they use small RNA guides to recognize targets. Initial insight into the architecture of …

PIWI-family proteins and their associated small RNAs (piRNAs) act in an evolutionarily
conserved innate immune mechanism to provide essential protection for germ-cell genomes …