The increased utilization of high-risk renal grafts for transplantation requires optimization of
pretransplant organ assessment strategies. Current decision-making methods to accept an …

Acute kidney injury (AKI) is an underestimated, yet important risk factor for development of
chronic kidney disease (CKD). Even after initial total recovery of renal function, some …

The G-protein coupled receptors (GPCRs) activated by free fatty acids (FFAs) have emerged
as new and exciting drug targets, due to their plausible translation from pharmacology to …

Introduction: Acute kidney injury (AKI) is a clinical syndrome characterized by the acute loss
of kidney function. AKI is increasingly frequent and is associated with impaired survival and …

The main side effect of cyclosporine A (CsA), a widely used immunosuppressive drug, is
nephrotoxicity. Early detection of CsA-induced acute nephrotoxicity is essential for stop or …

The ideal composition of the perfusate for normothermic kidney perfusion is unknown,
though the perfusate commonly used to perfuse human kidneys contains leukocyte-depleted …

To identify potentially transplantable organs in a pool of marginal kidneys, 33 porcine
slaughterhouse kidneys were perfused for 4 h with whole blood. During the normothermic …

Background Acute kidney injury (AKI) is a common clinical condition directly associated with
adverse outcomes. Several AKI biomarkers have been discovered, but their use in clinical …

Normothermic perfusion technology is a useful adjunct in kidney transplantation. It can
improve early graft function by upregulating protective mechanisms. It also has the …

Abstract Background Hydrogen sulfide (H 2 S) has recently been reported to demonstrate
both antiinflammatory and cytoprotective effects; however, its efficacy has not been well …