A review on the use of computational methods to characterize, design, and optimize tissue engineering scaffolds, with a potential in 3D printing fabrication

S Zhang, S Vijayavenkataraman… - Journal of Biomedical …, 2019 - Wiley Online Library
The design and fabrication of tissue engineering scaffolds is a highly complex process. In
order to provide a proper architecture for cells to grow, proliferate, and differentiate to form …

Vascularization in tissue engineering: The architecture cues of pores in scaffolds

P Xia, Y Luo - Journal of Biomedical Materials Research Part B …, 2022 - Wiley Online Library
Vascularization is a key event and also still a challenge in tissue engineering. Many efforts
have been devoted to the development of vascularization based on cells, growth factors …

Mechanical performance of highly permeable laser melted Ti6Al4V bone scaffolds

A Arjunan, M Demetriou, A Baroutaji, C Wang - Journal of the mechanical …, 2020 - Elsevier
Critically engineered stiffness and strength of a scaffold are crucial for managing
maladapted stress concentration and reducing stress shielding. At the same time, suitable …

Compression behavior of lattice structures produced by selective laser melting: X-ray tomography based experimental and finite element approaches

Y Amani, S Dancette, P Delroisse, A Simar, E Maire - Acta Materialia, 2018 - Elsevier
The compression behavior of hollow architectured structures obtained by additive
manufacturing was investigated in this work. Two face-centered cubic structures with the …

Three‐dimensional printed PCL‐hydroxyapatite scaffolds filled with CNT s for bone cell growth stimulation

EM Goncalves, FJ Oliveira, RF Silva… - … Research Part B …, 2016 - Wiley Online Library
A three‐phase [nanocrystalline hydroxyapatite (HA), carbon nanotubes (CNT), mixed in a
polymeric matrix of polycaprolactone (PCL)] composite scaffold produced by 3D printing is …

Computationally designed lattices with tuned properties for tissue engineering using 3D printing

PF Egan, VC Gonella, M Engensperger, SJ Ferguson… - PloS one, 2017 - journals.plos.org
Tissue scaffolds provide structural support while facilitating tissue growth, but are
challenging to design due to diverse property trade-offs. Here, a computational approach …

Finite element study of scaffold architecture design and culture conditions for tissue engineering

AL Olivares, È Marsal, JA Planell, D Lacroix - Biomaterials, 2009 - Elsevier
Tissue engineering scaffolds provide temporary mechanical support for tissue regeneration
and transfer global mechanical load to mechanical stimuli to cells through its architecture. In …

[HTML][HTML] Finite element method (FEM), mechanobiology and biomimetic scaffolds in bone tissue engineering

A Boccaccio, A Ballini, C Pappalettere… - … journal of biological …, 2011 - ncbi.nlm.nih.gov
Techniques of bone reconstructive surgery are largely based on conventional, non-cell-
based therapies that rely on the use of durable materials from outside the patient's body. In …

Extrusion based rapid prototyping technique: an advanced platform for tissue engineering scaffold fabrication

ME Hoque, YL Chuan, I Pashby - Biopolymers, 2012 - Wiley Online Library
Advances in scaffold design and fabrication technology have brought the tissue engineering
field stepping into a new era. Conventional techniques used to develop scaffolds inherit …

[HTML][HTML] A mechanobiology-based algorithm to optimize the microstructure geometry of bone tissue scaffolds

A Boccaccio, AE Uva, M Fiorentino… - … journal of biological …, 2016 - ncbi.nlm.nih.gov
Complexity of scaffold geometries and biological mechanisms involved in the bone
generation process make the design of scaffolds a quite challenging task. The most common …