Evolution of the RNA alternative decay cis element into a high-affinity target for the immunomodulatory protein Roquin
JN Tants, K Friedrich, J Neumann, A Schlundt - RNA biology, 2025 - Taylor & Francis
ABSTRACT RNA cis elements play pivotal roles in regulatory processes eg in transcriptional
and translational regulation. Two stem-looped cis elements, the constitutive and alternative …
and translational regulation. Two stem-looped cis elements, the constitutive and alternative …
The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules
P Peyda, CH Lin, K Onwuzurike… - Genes & …, 2025 - genesdev.cshlp.org
The Rbfox proteins regulate alternative pre-mRNA splicing by binding to the RNA element
GCAUG. In the nucleus, most of Rbfox is bound to the large assembly of splicing regulators …
GCAUG. In the nucleus, most of Rbfox is bound to the large assembly of splicing regulators …
Alternative splicing of PBRM1 mediates resistance to PD-1 blockade therapy in renal cancer
Alternative pre-mRNA splicing (AS) is a biological process that results in proteomic diversity.
However, implications of AS alterations in cancer remain poorly understood. Herein, we …
However, implications of AS alterations in cancer remain poorly understood. Herein, we …
Mutations to transcription factor MAX allosterically increase DNA selectivity by altering folding and binding pathways
R Hastings, AK Aditham, N DelRosso… - Nature …, 2025 - nature.com
Understanding how proteins discriminate between preferred and non-preferred ligands
('selectivity') is essential for predicting biological function and a central goal of protein …
('selectivity') is essential for predicting biological function and a central goal of protein …
High-throughput thermodynamic and kinetic measurements of transcription factor/DNA mutations reveal how conformational heterogeneity can shape motif selectivity
Transcription factors (TFs) bind DNA sequences with a range of affinities, yet the
mechanisms determining energetic differences between high-and low-affinity sequences …
mechanisms determining energetic differences between high-and low-affinity sequences …
[PDF][PDF] Translational study on the role of genetic and prenatal risk factors in neurodevelopmental psychiatric disorders
A Yotova - 2024 - d-nb.info
Neurodevelopmental psychiatric disorders (NPDs), such as attention deficit hyperactivity
disorder (ADHD), autism spectrum disorder (ASD), and schizophrenia (SCZ), and their …
disorder (ADHD), autism spectrum disorder (ASD), and schizophrenia (SCZ), and their …
[PDF][PDF] Fragment-based modelling of protein-RNA complexes for protein design
A Kravchenko - 2023 - theses.hal.science
3.2. 1 Coarse-Grained Representation ssRNA'TTRACT uses a coarse-grained
representation and a knowledge-based scoring function [168, 257, 256]. Each amino acid is …
representation and a knowledge-based scoring function [168, 257, 256]. Each amino acid is …