Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection

L Pardo-López, M Soberón… - FEMS microbiology …, 2013 - academic.oup.com
Bacillus thuringiensis bacteria are insect pathogens that produce different Cry and Cyt toxins
to kill their hosts. Here we review the group of three-domain Cry (3d-Cry) toxins. Expression …

Current models of the mode of action of Bacillus thuringiensis insecticidal crystal proteins: a critical review

V Vachon, R Laprade, JL Schwartz - Journal of invertebrate pathology, 2012 - Elsevier
Bacillus thuringiensis (Bt) Cry toxins constitute the active ingredient in the most widely used
biological insecticides and insect-resistant transgenic crops. A clear understanding of their …

Insecticidal Proteins from Bacillus thuringiensis and Their Mechanism of Action

A Bravo, S Pacheco, I Gómez, B Garcia-Gómez… - … and Use in the Field of …, 2017 - Springer
Abstract Bacillus thuringiensis (Bt) are Gram-positive bacteria that produce different
insecticidal proteins, named Cry, Vip, and Cyt, during the sporulation phase of growth. Here …

A major conformational change of N‐terminal helices of Bacillus thuringiensis Cry1Ab insecticidal protein is necessary for membrane insertion and toxicity

S Pacheco, I Gómez, M Soberón, A Bravo - The FEBS Journal, 2023 - Wiley Online Library
Pore forming toxins rely on oligomerization for membrane insertion to kill their targets.
Bacillus thuringiensis produces insecticidal Cry‐proteins composed of three domains that …

FOXA transcriptional factor modulates insect susceptibility to Bacillus thuringiensis Cry1Ac toxin by regulating the expression of toxin-receptor ABCC2 and ABCC3 …

J Li, Y Ma, W Yuan, Y Xiao, C Liu, J Wang… - Insect biochemistry and …, 2017 - Elsevier
Cry toxins produced by Bacillus thuringiensis (Bt) are insecticidal proteins widely used in
insect control. Recently, it was shown that ATP-binding cassette transporter proteins (ABC) …

Channel Formation in Cry Toxins: An Alphafold-2 Perspective

J Torres, W Surya, P Boonserm - International journal of molecular …, 2023 - mdpi.com
Bacillus thuringiensis (Bt) strains produce pore-forming toxins (PFTs) that attack insect pests.
Information for pre-pore and pore structures of some of these Bt toxins is available. However …

Cry1Ac toxin induces macrophage activation via ERK1/2, JNK and p38 mitogen-activated protein kinases

M Torres-Martínez, N Rubio-Infante… - The international journal …, 2016 - Elsevier
Abstract The Cry1Ac toxin from Bacillus thuringiensis is used commercially as a bio-
insecticide and is expressed in transgenic plants that are used for human and animal …

Coumarins as fluorescent labels of biomolecules

A Pereira, S Martins, AT Caldeira - Phytochemicals in human …, 2019 - books.google.com
Important areas such as environmental sciences, medicine, pharmacy, and cellular biology
are dependent on very sensitive analytical techniques. One of the most common …

Mechanistic insights into the first Lygus-active β-pore forming protein

A Jerga, D Chen, C Zhang, J Fu, JLK Kouadio… - Archives of biochemistry …, 2016 - Elsevier
The cotton pests Lygus hesperus and Lygus lineolaris can be controlled by expressing
Cry51Aa2. 834_16 in cotton. Insecticidal activity of pore-forming proteins is generally …

Differential protection of Cry1Fa toxin against Spodoptera frugiperda larval gut proteases by cadherin orthologs correlates with increased synergism

K Rahman, MAF Abdullah, S Ambati… - Applied and …, 2012 - Am Soc Microbiol
The Cry proteins produced by Bacillus thuringiensis (Bt) are the most widely used
biopesticides effective against a range of crop pests and disease vectors. Like chemical …