Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Chronic pulmonary diseases encompass different persistent and lethal diseases, including
chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic …

Pulmonary administration route has been extensively exploited for the treatment of local
lung diseases such as asthma, chronic obstructive pulmonary diseases and respiratory …

Membrane-disruptive peptides/peptidomimetics (MDPs) are antimicrobials or
anticarcinogens that present a general killing mechanism through the physical disruption of …

Bacterial infections constitute a threat to public health as antibiotics are becoming less
effective due to the emergence of antimicrobial resistant strains and biofilm and persister …

Antimicrobial peptides and proteins (APPs) are becoming increasingly important in targeting
multidrug-resistant (MDR) bacteria. APPs is a rapidly emerging area with novel molecules …

Bacteriophages (Phages) are antibacterial viruses that are unaffected by antibiotic drug
resistance. Many Phase I and Phase II phage therapy clinical trials have shown acceptable …

Pulmonary drug delivery can have several advantages over other administration routes, in
particular when using dry powder formulations. Such dry powder inhalation formulations …

A crosslinked ciprofloxacin (CIP) and polymethyltrimethoxysilane (PMTMS) with an inner
micro-arc oxidation (MAO) coating was designed to improve the corrosion resistance and …

Polymyxins are vital antibiotics for the treatment of multiresistant Gram-negative ESKAPE
pathogen infections. However, their clinical value is limited by their high nephrotoxicity and …