Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
NJ Hogrebe, M Ishahak, JR Millman - Cell Stem Cell, 2023 - cell.com
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …
Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …
tissue repair and regeneration. This has made macrophages a particularly attractive target …
[HTML][HTML] Biomaterials to enhance stem cell transplantation
The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …
medicine approaches and open promising avenues to repair, replace, and regenerate …
Strategies for durable β cell replacement in type 1 diabetes
Technological advancements in blood glucose monitoring and therapeutic insulin
administration have improved the quality of life for people with type 1 diabetes. However …
administration have improved the quality of life for people with type 1 diabetes. However …
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …
[HTML][HTML] Synthesis, properties, and biomedical applications of alginate methacrylate (ALMA)-based hydrogels: Current advances and challenges
Alginate methacrylate (ALMA) hydrogels have been prevalently used in various biomedical
applications, mainly due to their photocrosslinking ability. Not only this feature allows the …
applications, mainly due to their photocrosslinking ability. Not only this feature allows the …
[HTML][HTML] Type 1 diabetes and engineering enhanced islet transplantation
The development of new therapeutic approaches to treat type 1 diabetes mellitus (T1D)
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
relies on the precise understanding and deciphering of insulin-secreting β-cell biology, as …
Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression
Islet transplantation has been established as a viable treatment modality for type 1 diabetes.
However, the side effects of the systemic immunosuppression required for patients often …
However, the side effects of the systemic immunosuppression required for patients often …
Towards a functional cure for diabetes using stem cell-derived beta cells: are we there yet?
S Bourgeois, T Sawatani, A Van Mulders, N De Leu… - Cells, 2021 - mdpi.com
Diabetes mellitus is a pandemic metabolic disorder that results from either the autoimmune
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …
destruction or the dysfunction of insulin-producing pancreatic beta cells. A promising cure is …
[HTML][HTML] Emerging immunomodulatory strategies for cell therapeutics
Cellular therapies are poised to transform the field of medicine by restoring dysfunctional
tissues and treating various diseases in a dynamic manner not achievable by conventional …
tissues and treating various diseases in a dynamic manner not achievable by conventional …