Current Development of Thiazole-Containing Compounds as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus

H Liu, T Xu, Z Xue, M Huang, T Wang… - ACS Infectious …, 2024 - ACS Publications
The emergence of multi-drug-resistant bacteria is threatening to human health and life
around the world. In particular, methicillin-resistant Staphylococcus aureus (MRSA) causes …

Thiazole-based analogs as potential antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and their SAR elucidation

J Guo, Z Xie, W Ruan, Q Tang, D Qiao, W Zhu - European Journal of …, 2023 - Elsevier
In recent years, the overuse of antibiotics has resulted in the emergence of antibiotic
resistance, which is a serious global health problem. Methicillin-resistant Staphylococcus …

Thiazolidin-4-ones as potential antimicrobial agents: Experimental and in silico evaluation

C Tratrat, A Petrou, A Geronikaki, M Ivanov, M Kostić… - Molecules, 2022 - mdpi.com
Herein, we report computational and experimental evaluations of the antimicrobial activity of
twenty one 2, 3-diaryl-thiazolidin-4-ones. All synthesized compounds exhibited an …

Development of adamantane scaffold containing 1, 3, 4-thiadiazole derivatives: Design, synthesis, anti-proliferative activity and molecular docking study targeting …

MMS Wassel, YA Ammar, GAME Ali, A Belal… - Bioorganic …, 2021 - Elsevier
Abstract A new series of 1, 3, 4-thiadiazolo-adamantane derivatives were synthesized
through molecular hybridization approach, then used as starting material to synthesize …

Potential Fluorinated Anti‐MRSA Thiazolidinone Derivatives with Antibacterial, Antitubercular Activity and Molecular Docking Studies

V Kumar, P Shetty, A HS, S Chandra K… - Chemistry & …, 2022 - Wiley Online Library
MRSA infection is one of the alarming diseases in the current scenario. Identifying newer
molecules to treat MRSA infection is of urgent need. In the present study, we have designed …

Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase …

MMS Wassel, A Ragab, GAME Ali, ABM Mehany… - Journal of Molecular …, 2021 - Elsevier
A series of pyrazole derivatives 4, 5, 6, 12, 13, 14 as well as hydrazone derivatives 7, 10, 11
were synthesized starting from adamantane-1-carbohydrazide as the bioactive core. All …

Studies on the influence of the nuclearity of zinc (ii) hemi-salen complexes on some pivotal biological applications

BK Kundu, SM Mobin, S Mukhopadhyay - Dalton Transactions, 2020 - pubs.rsc.org
Though a large amount of literature has been reported on outlining the biological
significance of zinc (II) Schiff base complexes, yet none of them have explored the influence …

1, 3, 4-thiadiazole: A privileged scaffold for drug design and development

X Han, YL Yu, YS Hu, XH Liu - Current Topics in Medicinal …, 2021 - ingentaconnect.com
1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

Deep learning approach to the discovery of novel bisbenzazole derivatives for antimicrobial effect

T Barcin, MA Yucel, RH Ersan, MA Alagoz… - Journal of Molecular …, 2024 - Elsevier
Because of the growing bacterial resistance to antibiotics, the discovery of new antibiotics is
critical. The search for new antimicrobial drugs that are effective in treating new and existing …

Thiazole/thiadiazole/benzothiazole based thiazolidin-4-one derivatives as potential inhibitors of main protease of SARS-CoV-2

A Petrou, P Zagaliotis, NF Theodoroula, GA Mystridis… - Molecules, 2022 - mdpi.com
Since the time of its appearance until present, COVID-19 has spread worldwide, with over
71 million confirmed cases and over 1.6 million deaths reported by the World Health …