Targeting the holy triangle of quorum sensing, biofilm formation, and antibiotic resistance in pathogenic bacteria

RV Sionov, D Steinberg - Microorganisms, 2022 - mdpi.com
Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Efflux pump inhibitors for bacterial pathogens: From bench to bedside

A Sharma, VK Gupta, R Pathania - Indian Journal of Medical …, 2019 - journals.lww.com
With the advent of antibiotics, bacterial infections were supposed to be a thing of past.
However, this instead led to the selection and evolution of bacteria with mechanisms to …

Synergistic interactions of phytochemicals with antimicrobial agents: Potential strategy to counteract drug resistance

M Ayaz, F Ullah, A Sadiq, F Ullah, M Ovais… - Chemico-biological …, 2019 - Elsevier
The emergence of multidrug resistant (MDR) pathogens is a global threat and has created
problems in providing adequate treatment of many infectious diseases. Although the …

Tackling antibiotic resistance with compounds of natural origin: A comprehensive review

FJ Álvarez-Martínez, E Barrajón-Catalán, V Micol - Biomedicines, 2020 - mdpi.com
Drug-resistant bacteria pose a serious threat to human health worldwide. Current antibiotics
are losing efficacy and new antimicrobial agents are urgently needed. Living organisms are …

Antibiotic adjuvants: diverse strategies for controlling drug‐resistant pathogens

EE Gill, OL Franco… - Chemical biology & drug …, 2015 - Wiley Online Library
The growing number of bacterial pathogens that are resistant to numerous antibiotics is a
cause for concern around the globe. There have been no new broad‐spectrum antibiotics …

Inhibiting bacterial drug efflux pumps via phyto-therapeutics to combat threatening antimicrobial resistance

V Shriram, T Khare, R Bhagwat, R Shukla… - Frontiers in …, 2018 - frontiersin.org
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due
to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant …

Mechanisms and clinical uses of capsaicin

SK Sharma, AS Vij, M Sharma - European journal of pharmacology, 2013 - Elsevier
Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent
flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient …

Antibiotic potentiators against multidrug-resistant bacteria: discovery, development, and clinical relevance

M Chawla, J Verma, R Gupta, B Das - Frontiers in Microbiology, 2022 - frontiersin.org
Antimicrobial resistance in clinically important microbes has emerged as an unmet
challenge in global health. Extensively drug-resistant bacterial pathogens have cropped up …

Anti-virulence strategies to target bacterial infections

S Mühlen, P Dersch - How to Overcome the Antibiotic Crisis: Facts …, 2016 - Springer
Resistance of important bacterial pathogens to common antimicrobial therapies and the
emergence of multidrug-resistant bacteria are increasing at an alarming rate and constitute …

New roads leading to old destinations: efflux pumps as targets to reverse multidrug resistance in bacteria

G Spengler, A Kincses, M Gajdács, L Amaral - Molecules, 2017 - mdpi.com
Multidrug resistance (MDR) has appeared in response to selective pressures resulting from
the incorrect use of antibiotics and other antimicrobials. This inappropriate application and …