Colorectal cancer (CRC) is the third most frequent cancer type and the incidence of this
disease is increasing gradually per year in individuals younger than 50 years old. The …

Mutations in the MLH1 and MSH2 genes account for a majority of cases of families with
Lynch Syndrome. Germ‐line mutations in MSH6, PMS2 and MLH3 are responsible for …

Microsatellite instability (MSI) testing is useful for identifying patients with hereditary
nonpolyposis colorectal cancer and detecting sporadic colorectal cancer that develops …

Background Pathogenic germline variants in MLH1, MSH2 and MSH6 genes account for the
majority of Lynch syndrome (LS). In this first report from Pakistan, we investigated the …

BRCA1/BRCA2 genes were screened in 117 patients with breast cancer by sequencing.
Fourteen percent of patients tested positive for BRCA1/BRCA2 mutations. Four frame shift …

Lynch syndrome (LS) is an autosomal dominant syndrome that predisposes individuals to
development of cancers early in life. These cancers are mainly the following: colorectal …

Se considera que el cáncer colorrectal (CCR) es un problema mundial de salud pública; es
el tercer cáncer más común en hombres y el segundo en mujeres. Su distribución …

Colorectal cancer is the second leading cause of cancer‐related deaths in women and men
in Algeria. Lynch syndrome (LS) is an autosomal dominant disease caused by heterozygous …

Background/Aims: DNA mismatch repair (MMR) proteins are essential for repairing genetic
mutations that occur during DNA replication. Deficiency of MMR proteins results in a …

Purpose: Lynch syndrome LS is a hereditary cancer disorder characterized by increased
lifetime risk for various cancers. Colorectal cancer CRC is the most common cancer in LS …