[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …

[HTML][HTML] Role of phosphatidylcholine-DHA in preventing APOE4-associated Alzheimer's disease

RP Patrick - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Dietary and supplemental intake of the ω-3 fatty acid docosahexaenoic acid (DHA) reduces
risk of Alzheimer's disease (AD) and ameliorates symptoms. The apolipoprotein E (APOE) 4 …

Efficacy and blood plasmalogen changes by oral administration of plasmalogen in patients with mild Alzheimer's disease and mild cognitive impairment: a multicenter …

T Fujino, T Yamada, T Asada, Y Tsuboi, C Wakana… - …, 2017 - thelancet.com
Abstract Background Plasmalogens (Pls) reportedly decreased in postmortem brain and in
the blood of patients with Alzheimer's disease (AD). Recently we showed that intraperitoneal …

Potential role of plasmalogens in the modulation of biomembrane morphology

ZA Almsherqi - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Plasmalogens are a subclass of cell membrane glycerophospholipids that typically include
vinyl-ether bond at the sn-1 position and polyunsaturated fatty acid at the sn-2 position. They …

Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro

C Fourrier, J Remus-Borel, AD Greenhalgh… - Journal of …, 2017 - Springer
Background Neuroinflammatory processes are considered a double-edged sword, having
both protective and detrimental effects in the brain. Microglia, the brain's resident innate …

Plasma non-esterified docosahexaenoic acid is the major pool supplying the brain

CT Chen, AP Kitson, KE Hopperton… - Scientific reports, 2015 - nature.com
Despite being critical for normal brain function, the pools that supply docosahexaenoic acid
(DHA) to the brain are not agreed upon. Using multiple kinetic models in free-living adult …

Improvement of blood plasmalogens and clinical symptoms in Parkinson's disease by oral administration of ether phospholipids: A preliminary report

S Mawatari, S Ohara, Y Taniwaki, Y Tsuboi… - Parkinson's …, 2020 - Wiley Online Library
Introduction. Parkinson's disease (PD) is the second most common neurodegenerative
disease after Alzheimer's disease (AD). With the ageing of population, the frequency of PD is …

Enzymatic modification to produce health-promoting lipids from fish oil, algae and other new omega-3 sources: A review

N Castejón, FJ Señoráns - New biotechnology, 2020 - Elsevier
Lipases are a versatile class of enzymes that have aroused great interest in the food and
pharmaceutical industries due to their ability to modify and synthesize new lipids for …

[HTML][HTML] Plasmalogens eliminate aging-associated synaptic defects and microglia-mediated neuroinflammation in mice

J Gu, L Chen, R Sun, JL Wang, J Wang… - Frontiers in Molecular …, 2022 - frontiersin.org
Neurodegeneration is a pathological condition in which nervous system or neuron losses its
structure, function, or both leading to progressive neural degeneration. Growing evidence …

Marine fish-derived lysophosphatidylcholine: Properties, extraction, quantification, and brain health application

MK Ahmmed, M Hachem, F Ahmmed, A Rashidinejad… - Molecules, 2023 - mdpi.com
Long-chain omega-3 fatty acids esterified in lysophosphatidylcholine (LPC-omega-3) are
the most bioavailable omega-3 fatty acid form and are considered important for brain health …