Glioblastoma (GBM) is a devastating type of brain tumor, and current therapeutic treatments,
including surgery, chemotherapy, and radiation, are palliative at best. The design of effective …

Amplification of epidermal growth factor receptor (EGFR) and its active mutant EGFRvIII
occurs frequently in glioblastoma (GBM). While EGFR and EGFRvIII play critical roles in …

Cancer is a heavy burden for humans across the world with high morbidity and mortality.
Transcription factors including sex determining region Y (SRY)-related high-mobility group …

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent
technological advances, new insights into the molecular mechanisms underlying glioma …

Genome-wide molecular-profiling studies have revealed the characteristic genetic
alterations and epigenetic profiles associated with different types of gliomas. These …

Glioma stem cells (GSCs) are thought to underlie glioma initiation, evolution, and resistance
to existing therapies. Although functional evidence for GSCs is abundant, tumor …

Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes
that are “writers,”“erasers,” or “readers” of histone modification marks are common …

Glioblastoma therapies have remained elusive due to limitations in understanding
mechanisms of growth and survival of the tumorigenic population. Using CRISPR-Cas9 …

Zika virus (ZIKV) causes microcephaly by killing neural precursor cells (NPCs) and other
brain cells. ZIKV also displays therapeutic oncolytic activity against glioblastoma (GBM) stem …

The receptor for epidermal growth factor (EGFR) is a prime target for cancer therapy across
a broad variety of tumor types. As it is a tyrosine kinase, small molecule tyrosine kinase …