Base-pair opening is a conformational transition that is required for proper biological
function of nucleic acids. Hydrogen exchange, observed by NMR spectroscopic …

Base pairing in nucleic acids plays a crucial role in their structure and function. Differences
in the base‐pair opening and closing kinetics of individual double‐stranded DNA …

Improving the binding of metal complexes to DNA to boost cancer cell cytotoxicity requires
fine tuning of their structural and chemical properties. Copper has been used as a metal …

Azo dyes are defined by the presence of a characteristic N= N group. Sudan I and Sudan II
are synthetic azo dyes that have been used as coloring agents. Although animal toxicity …

Potential genotoxic impurities in medications are an increasing concern in the
pharmaceutical industry and regulatory bodies because of the risk of human carcinogenesis …

Conspectus DNA in its simplest form is an ensemble of nucleic acids, water, and ions, and
the conformation of DNA is dependent on the relative proportions of all three components …

Tetranucleotide TTTA and CCTG repeat expansions have been found in the coding region
of intercellular adhesion C protein gene of Staphylococcus aureus mutants and intron 1 of …

The 60th anniversary of DNA's discovery marks the conclusion of our first hour of discovery.
Each of tick of the year builds on our understanding; to think how differently we viewed …

The search for active demethylation processes lead to discovery of 5-hydroxymethylcytosine
(5hmC) adduct in the mammalian DNA. This lesion is formed post-replicatively by oxidation …

The interest in modified oligonucleotides continues in this review period, with over 1000
publications cited. A number of new internucleotide linkages have been described, and …