The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

Approximately one third of newly discovered drug molecules show insufficient water
solubility and therefore low oral bio-availability. Self-nano-emulsifying drug-delivery systems …

Hydrophobic ion pairing has emerged as a method to modulate the solubility of charged
hydrophilic molecules ranging in class from small molecules to large enzymes. Charged …

Since the development of self-emulsifying drug delivery systems (SEDDS) in 1980's, they
attract the attention of researchers in order to confront the challenge of poor water-solubility …

Aim The aim of this study was the formation and characterization of various ion pairs of
therapeutic peptides with different surfactants in order to reach a high payload in self …

Mucus is a dynamic barrier which covers and protects the underlying mucosal epithelial
membrane against bacteria and foreign particles. This protection mechanism extends to …

Background The biopharmaceuticals market has grown rapidly in recent years owing to the
low toxicity and high therapeutic efficacy of peptide and protein drugs. However, due to their …

Introduction The global biologics market has been ever increasing over the last decades
and is predicted to top Euro 350 by 2020. Facing this scenario, the parenteral route of …

Introduction Rapid advances in bioengineering enable the use of complex proteins as
therapeutic agents to treat diseases. Compared with conventional small molecule drugs …

The MYC oncoprotein functions as a master regulator of cellular transcription and executes
non-transcriptional tasks relevant to DNA replication and cell cycle regulation, thereby …