The mammary epithelium is highly responsive to local and systemic signals, which
orchestrate morphogenesis of the ductal tree during puberty and pregnancy. Based on …

Tumor heterogeneity impinges on prognosis, response to therapy, and metastasis. As such,
heterogeneity is one of the most important and clinically relevant areas of cancer research …

Human glioblastomas harbour a subpopulation of glioblastoma stem cells that drive
tumorigenesis. However, the origin of intratumoural functional heterogeneity between …

Different mechanisms contribute to intratumor heterogeneity, including genetic mutations,
the microenvironment, and the existence of subpopulations of cancer cells with increased …

High-throughput sequencing (HTS) of immune repertoires has enabled the quantitative
analysis of adaptive immune responses and offers the potential to revolutionize research in …

Recent work in the field of stem cell biology suggests that there is no single design for an
adult tissue stem cell hierarchy, and that different tissues employ distinct strategies to meet …

Tumours are often composed of a multitude of malignant clones that are genomically
unique, and only a few of them may have the ability to escape cancer therapy and grow as …

Most triple negative breast cancers (TNBCs) are aggressively metastatic with a high degree
of intra-tumoral heterogeneity (ITH), but how ITH contributes to metastasis is unclear. Here …

Adaptive drug-resistance mechanisms allow human tumors to evade treatment through
selection and expansion of treatment-resistant clones. Here, studying clonal evolution of …

The normal adult human mammary gland is a continuous bilayered epithelial system.
Bipotent and myoepithelial progenitors are prominent and unique components of the outer …