The Arp2/3 complex, which generates both branched but also linear actin filaments via
activation of SPIN90, is evolutionarily conserved in eukaryotes. Several factors regulate the …

Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …

Branched actin filaments are found in many key cellular structures. Branches are nucleated
by the Arp2/3 complex activated by nucleation-promoting factor (NPF) proteins and bound to …

How cells tightly control the formation and turnover of branched actin filament arrays to drive
cell motility, endocytosis, and other cellular processes is still not well understood. Here, we …

The actin cytoskeleton can form many different types of dynamic supramolecular arrays-from
linear bundles to branched actin filament networks which underlie its functional diversity and …

The cell's ability to change shape is a central feature in many cellular processes, including
cytokinesis, motility, migration, and tissue formation. The cell constructs a network of …

Stabilization of a branch structure would intuitively suggest a direct connection between
trunk and bough, but in actin filament networks, cortactin clamps the branching Arp2/3 …

Many enveloped viruses bud from the plasma membrane that is tightly associated with a
dense and thick actin cortex. This actin network represents a significant challenge for …

Cell polarity is crucial for gastric mucosal barrier integrity and mainly regulated by polarity-
regulating kinase partitioning-defective 1b (Par1b). During infection, the carcinogen …

The inhibitors, CK-666 and CK-869, are widely used to probe the function of Arp2/3 complex
mediated actin nucleation in vitro and in cells. However, in mammals, the Arp2/3 complex …