TP53, which encodes the tumour-suppressor protein p53, is the most frequently mutated
gene across all cancer types. The presence of mutant p53 predisposes to cancer …

The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and
cell division. A stress signal is transmitted to the p53 protein by post-translational …

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast
and ovarian cancer, has been identified by positional cloning methods. Probable …

DNA damage-induced acetylation of p53 protein leads to its activation and either growth
arrest or apoptosis. We show here that the protein product of the gene hSIR2 SIRT1, the …

Nuclear lamin B1 (LB1) is a major structural component of the nucleus that appears to be
involved in the regulation of many nuclear functions. The results of this study demonstrate …

Reprogramming somatic cells to induced pluripotent stem (iPS) cells has been
accomplished by expressing pluripotency factors and oncogenes,,,,,,,, but the low frequency …

As the tale of p53 unfolds, it becomes ever more intriguing. Although our understanding of
the critical and complex roles played by p53 is progressing rapidly, new findings continue to …

Abstract p53, the tumour suppressor and transcriptional activator, is regulated by numerous
post-translational modifications, including lysine methylation,. Histone lysine methylation …

Aneuploidy is a hallmark of cancer, although its effects on tumorigenesis are unclear. Here,
we investigated the relationship between aneuploidy and cancer development using cells …

The p53 guardian of the genome is inactivated in the majority of cancers, mostly through
missense mutations that cause single residue changes in the DNA binding core domain of …