Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

Biological aging involves an interplay of conserved and targetable molecular mechanisms,
summarized as the hallmarks of aging. Metformin, a biguanide that combats age-related …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-
lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular …

Metformin is the oldest and most commonly used first-line antidiabetic drug because of its
good clinical efficacy, high safety, low cost and easy access. At the same time, in recent …

Metformin is the most widely prescribed drug to treat patients with type II diabetes, for whom
retrospective studies suggest that metformin may have anticancer properties. However, in …

Metformin has been used for nearly a century and is now the most widely prescribed oral
anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and …

We investigated, for the first time, the potential for a hydrogel-forming microneedle (MN)
patch to deliver the high-dose drug metformin HCl transdermally in a sustained manner. This …

Background: Recent changes to the US Food and Drug Administration boxed warning for
metformin will increase its use in persons with historical contraindications or precautions …

Choices for the treatment of type 2 diabetes mellitus (T2DM) have multiplied as our
understanding of the underlying pathophysiologic defects has evolved. Treatment should …