Recent advances in extracellular vesicle engineering and its applications to regenerative medicine

WK Rhim, JY Kim, SY Lee, SG Cha, JM Park… - Biomaterials …, 2023 - spj.science.org
Extracellular vesicles (EVs) are nanosized particles that are released from cells and reflect
the characteristics of the mother cell. Recently, the EVs have been used in several types of …

Advances in Extracellular-Vesicles-Based Diagnostic and Therapeutic Approaches for Ocular Diseases

Y Su, M Chen, W Xu, P Gu, X Fan - ACS nano, 2024 - ACS Publications
Extracellular vesicles (EVs) are nanoscale membrane vesicles of various sizes that can be
secreted by most cells. EVs contain a diverse array of cargo, including RNAs, lipids …

[HTML][HTML] Neural stem cell-derived extracellular vesicles: the light of central nervous system diseases

Y Li, B Fang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Central nervous system (CNS) diseases are the leading cause of death worldwide. By
performing compensatory functions and improving the inflammatory microenvironment, the …

Standardization approaches for extracellular vesicle loading with oligonucleotides and biologics

J Roerig, M Schulz‐Siegmund - Small, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are widely recognized for their potential as drug delivery
systems. EVs are membranous nanoparticles shed from cells. Among their natural features …

[HTML][HTML] Engineered mesenchymal stem cell-derived small extracellular vesicles for diabetic retinopathy therapy through HIF-1α/EZH2/PGC-1α pathway

F Sun, Y Sun, X Wang, J Zhu, S Chen, Y Yu, M Zhu… - Bioactive Materials, 2024 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness worldwide with limited treatment
options. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) hold …

[HTML][HTML] Emerging role of extracellular vesicles in diabetic retinopathy

J Zhu, J Huang, Y Sun, W Xu, H Qian - Theranostics, 2024 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR), a complex complication of diabetes mellitus (DM), is a leading
cause of adult blindness. Hyperglycemia triggers DR, resulting in microvascular damage …

Recent advances in extracellular vesicles for therapeutic cargo delivery

HI Kim, J Park, Y Zhu, X Wang, Y Han… - Experimental & Molecular …, 2024 - nature.com
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest
in the field of biomedical research due to their unique properties, including biocompatibility …

[HTML][HTML] Utilizing extracellular vesicles as a drug delivery system in glaucoma and RGC degeneration

E Durmaz, L Dribika, M Kutnyanszky, B Mead - Journal of Controlled …, 2024 - Elsevier
Retinal diseases are the leading cause of blindness, resulting in irreversible degeneration
and death of retinal neurons. One such cell type, the retinal ganglion cell (RGC), is …

Engineering approaches for exosome cargo loading and targeted delivery: biological versus chemical perspectives

W Ahmed, A Mushtaq, S Ali, N Khan… - ACS Biomaterials …, 2024 - ACS Publications
Exosomes are nanoscale membrane bound vesicles secreted by almost all types of cells.
Their unique attributes, such as minimal immunogenicity and compatibility with biological …

Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration

Y Sun, Y Sun, S Chen, Y Yu, Y Ma, F Sun - Journal of Nanobiotechnology, 2023 - Springer
Photoreceptor apoptosis is an important pathogenesis of retinal degeneration and a primary
cause of vision loss with limited treatment methods. Mesenchymal stem/stromal cells …