Despite objective responses to poly (ADP-ribose) polymerase (PARP) inhibition and
improvements in progression-free survival (PFS) compared to standard chemotherapy in …

The majority of processes that occur in daily cell life are modulated by hundreds to
thousands of dynamic protein–protein interactions (PPI). The resulting protein complexes …

Eukaryotic protein phosphorylation modulates nearly every major biological process.
Phosphorylation regulates protein activity, mediates cellular signal transduction, and …

The endoplasmic reticulum (ER) employs a diverse proteome landscape to orchestrate
many cellular functions, ranging from protein and lipid synthesis to calcium ion flux and inter …

Single cell proteomics is a powerful tool with potential for markedly enhancing
understanding of cellular processes. Here we report the development and application of …

The intimate association between the endoplasmic reticulum (ER) and mitochondrial
membranes at ER-Mitochondria contact sites (ERMCS) is a platform for critical cellular …

Cells harbor two systems for fatty acid synthesis, one in the cytoplasm (catalyzed by fatty
acid synthase, FASN) and one in the mitochondria (mtFAS). In contrast to FASN, mtFAS is …

ER protein homeostasis (proteostasis) is essential for proper folding and maturation of
proteins in the secretory pathway. Loss of ER proteostasis can lead to the accumulation of …

Cancer-associated mutations that stabilize NRF2, an oxidant defense transcription factor,
are predicted to promote tumor development. Here, utilizing 3D cancer spheroid models …

Phosphorylation is a post-translational modification with a vital role in cellular signaling.
Isobaric labeling-based strategies, such as tandem mass tags (TMT), can measure the …