Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Tumor necrosis factor (TNF) is a central regulator of immunity. Due to its dominant pro-
inflammatory effects, drugs that neutralize TNF were developed and are clinically used to …

Virtually all phases of spinal cord injury pathogenesis, including inflammation, cell
proliferation and differentiation, as well as tissue remodeling, are mediated in part by …

Spinal cord injury (SCI) damages multiple structures at the lesion site, including ascending,
descending, and propriospinal axons; interrupting the conduction of information up and …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common cause of dementia. Accumulating experimental evidence shows the important …

Given the increase in life expectancy, aging with a pre-existing spinal cord injury (SCI) is
becoming more common. This condition is challenging as compromised health status and …

A substantial number of individuals have long-lasting adverse effects from a traumatic brain
injury (TBI). Depression is one of these long-term complications that influences many …

Infections impair neurological outcome and increase mortality after spinal cord injury (SCI).
Emerging data show that pathogens more easily infect individuals with SCI because SCI …

After spinal cord injury (SCI), normally innocuous visceral or somatic stimuli can trigger
uncontrolled reflex activation of sympathetic circuitry, causing pathological dysautonomia …

Simple Summary Spinal cord injury can result in an increased vulnerability to infections, but
until recently the biological mechanisms behind this observation were not well defined …