Mitochondria as a cellular hub in infection and inflammation
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …
dynamic networks where they adapt energy production based on the cell's needs. They are …
The role of autophagy in viral infections
T Chen, S Tu, L Ding, M Jin, H Chen, H Zhou - Journal of biomedical …, 2023 - Springer
Autophagy is an evolutionarily conserved catabolic cellular process that exerts antiviral
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …
functions during a viral invasion. However, co-evolution and co-adaptation between viruses …
The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …
Possible pathogenesis and prevention of long COVID: SARS-CoV-2-induced mitochondrial disorder
TH Chen, CJ Chang, PH Hung - International journal of molecular …, 2023 - mdpi.com
Patients who have recovered from coronavirus disease 2019 (COVID-19) infection may
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …
experience chronic fatigue when exercising, despite no obvious heart or lung abnormalities …
Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality
S Shenoy - Inflammation research, 2020 - Springer
Background Decline in mitochondrial function occurs with aging and may increase mortality.
We discuss mitochondrial contribution to Covid-19 sepsis, specifically the complex …
We discuss mitochondrial contribution to Covid-19 sepsis, specifically the complex …
Elucidating the neuropathologic mechanisms of SARS-CoV-2 infection
M Pacheco-Herrero, LO Soto-Rojas… - Frontiers in …, 2021 - frontiersin.org
The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus …
(SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus …
Pathophysiological involvement of host mitochondria in SARS-CoV-2 infection that causes COVID-19: A comprehensive evidential insight
SARS-CoV-2 is a positive-strand RNA virus that infects humans through the nasopharyngeal
and oral route causing COVID-19. Scientists left no stone unturned to explore a targetable …
and oral route causing COVID-19. Scientists left no stone unturned to explore a targetable …
Differential co-expression network analysis reveals key hub-high traffic genes as potential therapeutic targets for COVID-19 pandemic
Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …
Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples
SARS-CoV-2 induces a muted innate immune response compared to other respiratory
viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate …
viruses. Mitochondrial dynamics might partially mediate this effect of SARS-CoV-2 on innate …
Inflammation causes remodeling of mitochondrial cytochrome c oxidase mediated by the bifunctional gene C15orf48
SA Clayton, KK Daley, L MacDonald… - Science …, 2021 - science.org
Dysregulated mitochondrial function is a hallmark of immune-mediated inflammatory
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …
diseases. Cytochrome c oxidase (C c O), which mediates the rate-limiting step in …