Colorectal cancer (CRC) remains one of the most prevalent cancers worldwide. In sporadic
CRC, mutations frequently occur in the DNA mismatch repair (MMR) pathway. In addition …

In the early years of the molecular biology revolution, cancer research was mainly focused
on genetic changes (ie, those that altered DNA sequences). Although this has been …

Colorectal cancer (CRC) is one of the leading cause of cancer death worldwide. Currently,
no effective early diagnostic biomarkers are available for colorectal carcinoma. Therefore …

Purpose: To assess prognostic roles of various KRAS oncogene mutations in colorectal
cancer, BRAF mutation status must be controlled for because BRAF mutation is associated …

Abstract Purpose: Mutations in PIK3CA [the gene encoding the p110α catalytic subunit of
phosphatidylinositide-3-kinase (PI3K)] play an important role in colorectal carcinogenesis …

Background: Distant metastasis is the major cause of mortality in colorectal cancer (CRC).
We performed a systemic, comprehensive discovery for expression patterns of metastasis …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths worldwide.
Recently, microRNAs (miRNAs) are reported to be altered and act as potential biomarkers in …

Gene expression is in part regulated by microRNAs (miRNAs). This review summarizes the
current knowledge of miRNAs in colorectal cancer (CRC); their role as growth regulators, the …

BRAF is an important gene in colorectal cancers (CRCs) that is associated with molecular
characterization and resistance to targeted therapy. Although microRNAs (miRNAs) are …

Colorectal cancer (CRC) is one of the most potentially curable cancers, yet it remains the
fourth most common overall cause of cancer death worldwide. The identification of robust …