Mixed integer programming improves comprehensibility and plan quality in inverse optimization of prostate HDR brachytherapy

BL Gorissen, D Den Hertog… - Physics in Medicine & …, 2013 - iopscience.iop.org
Current inverse treatment planning methods that optimize both catheter positions and dwell
times in prostate HDR brachytherapy use surrogate linear or quadratic objective functions …

A linear programming model for optimizing HDR brachytherapy dose distributions with respect to mean dose in the DVH‐tail

Å Holm, T Larsson, ÅC Tedgren - Medical physics, 2013 - Wiley Online Library
Purpose: Recent research has shown that the optimization model hitherto used in high‐dose‐
rate (HDR) brachytherapy corresponds weakly to the dosimetric indices used to evaluate the …

Fast and insightful bi-objective optimization for prostate cancer treatment planning with high-dose-rate brachytherapy

NH Luong, T Alderliesten, BR Pieters, A Bel… - Applied Soft …, 2019 - Elsevier
Purpose: Prostate high-dose-rate brachytherapy (HDR-BT) planning involves determining
the movement that a high-strength radiation stepping source travels through the patient's …

Dwell time modulation restrictions do not necessarily improve treatment plan quality for prostate HDR brachytherapy

M Balvert, BL Gorissen, D Den Hertog… - Physics in Medicine & …, 2014 - iopscience.iop.org
Inverse planning algorithms for dwell time optimisation in interstitial high-dose-rate (HDR)
brachytherapy may produce solutions with large dwell time variations within catheters, which …

Improving the quality, efficiency and robustness of radiation therapy planning and delivery through mathematical optimization

M Balvert - 2017 - research.tilburguniversity.edu
Radiation therapy is an established cancer treatment which exploits ionizing radiation to
harm tumourous cells. As radiation can pass through healthy tissue to reach the tumour, this …