Many patients with chest pain undergoing coronary angiography do not show significant
obstructive coronary lesions. A substantial proportion of these patients have abnormalities in …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the neural tissue. It separates the peripheral circulatory system from the …

Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may
represent the first recognizable manifestation of a progressive disease of the small …

Inflammation is increasingly implicated as a risk factor for dementia, stroke, and small vessel
disease (SVD). However, the underlying mechanisms and causative pathways remain …

Increasing evidence suggests that vascular risk factors contribute to neurodegeneration,
cognitive impairment and dementia. While there is considerable overlap between features of …

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

Small vessel diseases (SVDs) are a group of disorders that result from pathological
alteration of the small blood vessels in the brain, including the small arteries, capillaries and …

Cerebral small vessel disease (cSVD) has a crucial role in lacunar stroke and brain
hemorrhages and is a leading cause of cognitive decline and functional loss in elderly …

The term cerebral small vessel disease (SVD) describes a range of neuroimaging,
pathological, and associated clinical features. Clinical features range from none, to discrete …

Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …