Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Glucocorticoids (GCs) are a class of steroid hormones that regulate key physiological
processes such as metabolism, immune function, and stress responses. The effects of GCs …

Chromatin is highly dynamic, undergoing continuous global changes in its structure and
type of histone and DNA modifications governed by processes such as transcription, repair …

Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …

Background Multiple myeloma (MM) is an incurable plasma cell malignancy. Although
Dexamethasone (Dex) is the most widely used therapeutic drug in MM treatment, patients …

Abstract Treatment of prostate cancer relies predominantly on the inhibition of androgen
receptor (AR) signaling. Despite the initial effectiveness of the antiandrogen therapies, the …

Steroid receptors (SRs) constitute an important class of signal-dependent transcription
factors (TFs). They regulate a variety of key biological processes and are crucial drug targets …

Because of their ability to induce lymphocyte apoptosis, glucocorticoids (GC) are widely
used to treat hematological malignancies such as lymphomas and multiple myeloma. Their …

Hematologic malignancies are a large and heterogeneous group of neoplasms
characterized by complex pathogenetic mechanisms. The abnormal regulation of epigenetic …

FKBP51 is an important inhibitor of the glucocorticoid receptor (GR) signaling. High FKBP51
levels are associated to stress-related disorders, which are linked to GR resistance. SUMO …