Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights

SF De Medeiros, RJ Norman - Human reproduction update, 2009 - academic.oup.com
BACKGROUND Human chorionic gonadotrophin (hCG) is measured in serum and urine for
the early detection of ectopic pregnancy, patients with higher risk of miscarriage, embryos or …

Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements

JF O'Connor, S Birken, JW Lustbader… - Endocrine …, 1994 - academic.oup.com
SINCE the discovery of human chorionic gonadotropin (hCG) by Hirose (1) and Ascheim
and Zondek (2) nearly three quarters of a century ago, its measurement has been the basis …

Standardization of protein immunoprocedures choriogonadotropin (Cg)

UHÅK Stenman, JM Bidart, S Birken… - … Journal of Clinical …, 1993 - Taylor & Francis
The objectives of this report is to improve the quality of immunochemical deter minations of
proteins. Procedures for determination of the various molecular forms hCG were chosen as …

Loss of human chorionic gonadotropin in urine during storage at− 20 C

A Lempiäinen, K Hotakainen, H Alfthan… - Clinica Chimica Acta, 2012 - Elsevier
BACKGROUND: Quantitative determination of human chorionic gonadotropin (hCG) in urine
is used in population studies of pregnancy disorders and in doping control. For these …

Design of stable biologically active recombinant lutropin analogs

V Garcia-Campayo, A Sato, B Hirsch, T Sugahara… - Nature …, 1997 - nature.com
Glycoprotein hormones are noncovalent heterodimers comprised of a common α subunit
and a hormone-specific β subunit. Secretion and biologic action of these hormones are …

Urinary β‐core human chorionic gonadotrophin: a new approach to Down's syndrome screening

HS Cuckle, RK Iles, T Chard - Prenatal diagnosis, 1994 - Wiley Online Library
Human chorionic gonadotrophin (hCG) is the most discriminatory maternal serum marker of
Down's syndrome. We have carried out a study to establish whether urinary β‐core‐hCG, a …

Determination of hyperglycosylated human chorionic gonadotropin produced by malignant gestational trophoblastic neoplasias and male germ cell tumors using a …

LS Kelly, S Birken, D Puett - Molecular and cellular endocrinology, 2007 - Elsevier
The ability to reliably detect aberrant glycosylation of human chorionic gonadotropin (hCG)
may have profound implications for the diagnosis and monitoring of malignant gestational …

Are the cytokines interleukin-6 and angiogenin stable in frozen amniotic fluid?

CY Spong, A Ghidini, M Ossandon, CN Walker… - American journal of …, 1998 - Elsevier
OBJECTIVE: To determine the stability of cytokines in frozen stored amniotic fluid samples,
we measured angiogenin, a potent inducer of neovascularization and interleukin-6, an …

The expression of the urinary forms of human luteinizing hormone beta fragment in various populations as assessed by a specific immunoradiometric assay.

JF O'Connor, G Kovalevskaya, S Birken… - Human reproduction …, 1998 - academic.oup.com
Human gonadotrophins undergo metabolic transformations which result in the presence of
several smaller, structurally and immunologically related forms of gonadotrophins in the …

Real-time and high-sensitive colorimetric sensor based on photonic crystal for amniotic fluid identification

Y Li, X Wang, L Li, J Wang, X Dong, Z Meng… - Microchemical Journal, 2024 - Elsevier
In this study, we proposed a pH-responsive photonic crystal hydrogel sensor (PCHs) to
conveniently and accurately recognize the amniotic fluid from urine of parturient women …