The role of protein phosphatases in pathogenic bacteria has been studied extensively over
the last two decades. Ser/Thr and Tyr phosphatases are associated with growth and …

Mycobacterium tuberculosis (Mtb) is an obligate human pathogen killing millions of people
annually. Treatment for tuberculosis is lengthy and complicated, involving multiple drugs …

Macrophage-mediated innate immune responses play crucial roles in host defense against
pathogens. Recent years have seen an explosion of host proteins that act as restriction …

Originally identified as a low molecular weight acid phosphatase, LMW-PTP is actually a
protein tyrosine phosphatase that acts on many phosphotyrosine-containing cellular …

Isoniazid (INH), one of the first-line drugs used for the treatment of tuberculosis, is a prodrug
which is activated by the intracellular KatG enzyme of Mycobacterium tuberculosis. The …

Understanding allostery in the Mycobacterium tuberculosis low molecular weight protein
tyrosine phosphatase (MptpA) is a subject of great interest since MptpA is one of two protein …

Rhodococcus equi (R. equi) is an important pulmonary pathogen in foals that often leads to
the death of the horse. The bacterium harbors a virulence plasmid that encodes numerous …

Mycobacterial Ser/Thr kinases play a critical role in bacterial physiology and pathogenesis.
Linking kinases to the substrates they phosphorylate in vivo, thereby elucidating their exact …

The ability of the bacterial phytopathogen Xanthomonas campestris pv. campestris (Xcc) to
cause disease is dependent on the type III secretion system (T3SS). Proteins of the Xcc …

The Mycobacterium tuberculosis low-molecular weight protein tyrosine phosphatase
(MptpA) is responsible for the inhibition of phagosome-lysosome fusion and is essential for …