Ascorbic acid is synthesised by eukaryotes, the known exceptions being primates and some
other animal groups which have lost functional gulonolactone oxidase. Prokaryotes do not …

The recent increase in genomic data is revealing an unexpected perspective of gene loss as
a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This …

There are limited proven therapies for COVID-19. Vitamin C's antioxidant, anti-inflammatory
and immunomodulating effects make it a potential therapeutic candidate, both for the …

It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …

Throughout evolution, a number of animals including humans have lost the ability to
synthesize ascorbic acid (ascorbate, vitamin C), an essential molecule in the physiology of …

Sepsis, a life-threatening organ dysfunction due to a dysregulated host response to
infection, is a leading cause of morbidity and mortality worldwide. Decades of research have …

A wide variety of the roots and tubers plays a major role in human diet, animal feed, and
industrial raw materials. Sweet potatoes (SPs) play an immense role in human diet and …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

Helicobacter pylori is a class one carcinogen which causes chronic atrophic gastritis, gastric
intestinal metaplasia, dysplasia and adenocarcinoma. The mechanisms by which H. pylori …

Significance: Protein S-nitrosylation, the oxidative modification of cysteine by nitric oxide
(NO) to form protein S-nitrosothiols (SNOs), mediates redox-based signaling that conveys, in …