The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases
Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
Natural product-based pharmacological studies for neurological disorders
Central nervous system (CNS) disorders and diseases are expected to rise sharply in the
coming years, partly because of the world's aging population. Medicines for the treatment of …
coming years, partly because of the world's aging population. Medicines for the treatment of …
Chemico-pharmacological and computational studies of Ophiorrhiza fasciculata D. Don and Psychotria silhetensis Hook. f. focusing cytotoxic, thrombolytic, anti …
The current study sought to examine the pharmacological potentials of crude methanolic
extracts of Ophiorrhiza fasciculata and Psychotria silhetensis, as well as their various solvent …
extracts of Ophiorrhiza fasciculata and Psychotria silhetensis, as well as their various solvent …
Advances in the discovery of heterocyclic-based drugs against Alzheimer's disease
Introduction Alzheimer's disease is a multifactorial neurodegenerative disorder
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …
characterized by beta-amyloid accumulation and tau protein hyperphosphorylation. The …
Phenolic Constituents from Wendlandia tinctoria var. grandis (Roxb.) DC. Stem Deciphering Pharmacological Potentials against Oxidation, Hyperglycemia, and …
Wendlandia tinctoria var. grandis (Roxb.) DC.(Family: Rubiaceae) is a semi-evergreen
shrub distributed over tropical and subtropical Asia. The present research intended to …
shrub distributed over tropical and subtropical Asia. The present research intended to …
Evolution of lipid nanoparticles as charioteers of Alzheimer's disease therapeutics
Alzheimer's disease (AD) is a global health crisis, one of the most complex
neurodegenerative diseases that significantly affects populations worldwide without any age …
neurodegenerative diseases that significantly affects populations worldwide without any age …
In silico molecular docking and dynamic simulation of anti-cholinesterase compounds from the extract of Catunaregam spinosa for possible treatment of Alzheimer's …
S Thandivel, P Rajan, T Gunasekar, A Arjunan, S Khute… - Heliyon, 2024 - cell.com
Abstract Alzheimer's disease (AD), is characterized by a progressive loss of cognitive
abilities as well as behavioral symptoms including disorientation, trouble solving problems …
abilities as well as behavioral symptoms including disorientation, trouble solving problems …
Phytochemical and pharmacological profiling of Trewia nudiflora Linn. leaf extract deciphers therapeutic potentials against thrombosis, arthritis, helminths, and …
The objective of the current study was to examine the phytochemical and in vitro
thrombolytic, anti-arthritic, anthelmintic, and insecticidal effects of Trewia nudiflora (TN) …
thrombolytic, anti-arthritic, anthelmintic, and insecticidal effects of Trewia nudiflora (TN) …
Recent advances in potential enzymes and their therapeutic inhibitors for the treatment of Alzheimer's disease
Abstract Alzheimer's disease (AD), a chronic neurodegenerative disease, is clinically
characterized by loss of memory and learning ability among other neurological deficits …
characterized by loss of memory and learning ability among other neurological deficits …
Synthesis and biological studies of pyrimidine derivatives targeting metabolic enzymes
E Korkusuz, Y Sert, S Arslan, H Aydın… - Archiv der …, 2024 - Wiley Online Library
Novel synthesized pyrimidine derivatives were investigated against carbonic anhydrase
isoenzymes I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase …
isoenzymes I and II (hCA I and II), acetylcholinesterase (AChE), butyrylcholinesterase …