Facilitating next‐generation pre‐exposure prophylaxis clinical trials using HIV recent infection assays: a consensus statement from the Forum HIV Prevention Trial …
Standard‐of‐care HIV pre‐exposure prophylaxis (PrEP) is highly efficacious, but uptake of
and persistence on a daily oral pill is low in many settings. Evaluation of alternate PrEP …
and persistence on a daily oral pill is low in many settings. Evaluation of alternate PrEP …
Antibody Fc effector functions and IgG3 associate with decreased HIV-1 risk
HVTN 505 is a preventative vaccine efficacy trial testing DNA followed by recombinant
adenovirus serotype 5 (rAd5) in circumcised, Ad5-seronegative men and transgendered …
adenovirus serotype 5 (rAd5) in circumcised, Ad5-seronegative men and transgendered …
Hinge length contributes to the phagocytic activity of HIV-specific IgG1 and IgG3 antibodies
Antibody functions such as neutralization require recognition of antigen by the Fab region,
while effector functions are additionally mediated by interactions of the Fc region with …
while effector functions are additionally mediated by interactions of the Fc region with …
[HTML][HTML] Development of antibody biomarkers of long term and recent dengue virus infections
EJM Nascimento, JW Huleatt, MT Cordeiro… - Journal of virological …, 2018 - Elsevier
Dengue virus (DENV) infections elicit antibody responses to the non-structural protein 1
(NS1) that are associated with protection against disease. However, the antibody isotypes …
(NS1) that are associated with protection against disease. However, the antibody isotypes …
Performance evaluation of the Asante Rapid Recency Assay for verification of HIV diagnosis and detection of recent HIV-1 infections: Implications for epidemic control
EL Yufenyuy, M Detorio, T Dobbs… - PLOS Global Public …, 2022 - journals.plos.org
We previously described development of a rapid test for recent infection (RTRI) that can
diagnose HIV infection and detect HIV-1 recent infections in a single device. This technology …
diagnose HIV infection and detect HIV-1 recent infections in a single device. This technology …
Loss of HIV candidate vaccine efficacy in male macaques by mucosal nanoparticle immunization rescued by V2-specific response
Systemic vaccination of macaques with V1-deleted (ΔV1) envelope immunogens reduce the
risk of SIVmac251 acquisition by approximately 60%, with protective roles played by V2 …
risk of SIVmac251 acquisition by approximately 60%, with protective roles played by V2 …
[HTML][HTML] Focusing HIV-1 Gag T cell responses to highly conserved regions by DNA vaccination in HVTN 119
BACKGROUND An HIV-1 DNA vaccine composed of 7 highly conserved, structurally
important elements (conserved elements, CE) of p24Gag was tested in a phase I …
important elements (conserved elements, CE) of p24Gag was tested in a phase I …
Polyclonal broadly neutralizing antibody activity characterized by Cd4 binding site and V3-glycan antibodies in a subset of hiv-1 virus controllers
TE Nyanhete, RJ Edwards, CC LaBranche… - Frontiers in …, 2021 - frontiersin.org
Broadly neutralizing antibodies (bNAbs), known to mediate immune control of HIV-1
infection, only develop in a small subset of HIV-1 infected individuals. Despite being …
infection, only develop in a small subset of HIV-1 infected individuals. Despite being …
Cholera toxin B scaffolded, focused SIV V2 epitope elicits antibodies that influence the risk of SIVmac251 acquisition in macaques
MA Rahman, M Becerra-Flores, Y Patskovsky… - Frontiers in …, 2023 - frontiersin.org
Introduction An efficacious HIV vaccine will need to elicit a complex package of innate,
humoral, and cellular immune responses. This complex package of responses to vaccine …
humoral, and cellular immune responses. This complex package of responses to vaccine …
Impact of adjuvants on the biophysical and functional characteristics of HIV vaccine-elicited antibodies in humans
Adjuvants can alter the magnitude, characteristics, and persistence of the humoral response
to protein vaccination. HIV vaccination might benefit from tailored adjuvant choice as raising …
to protein vaccination. HIV vaccination might benefit from tailored adjuvant choice as raising …