Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Glutamic acid is an amino acid with multiple biological roles. In the animal world, it links the
metabolism of carbon and nitrogen and, depending on the need, serves either as a source …

Metabolism of glutamate, the main excitatory neurotransmitter and precursor of GABA, is
exceedingly complex and highly compartmentalized in brain. Maintenance of these …

We present a comprehensive overview of the hierarchical network of intracellular processes
revolving around central nitrogen metabolism in Escherichia coli. The hierarchy intertwines …

1. The concentrations of the oxidized and reduced substrates of the 'malic'enzyme (EC 1.1.
1.40) and isocitrate dehydrogenase (EC 1.1. 1.42) were measured in freeze-clamped rat …

The pyridine nucleotide-disulfide oxidoreductases form a family of homo-dimeric fla
voenzymes having a redox-active disulfide and a FAD in each monomer. The well …

Publisher Summary This chapter discusses the types of investigations with major emphasis
on recent studies that include elucidation of complete or partial amino acid sequences of the …

Amino acid biosynthesis initiates with the reductive amination of α‐ketoglutarate with
ammonia to produce glutamate. However, the other α‐keto acids derived from the glyoxylate …

Hepatocytes isolated from fed or starved rats were rapidly lysed using the recently described
technique of turbulent flow (ME Tischler, P. Hecht, and JR Williamson, 1977, Arch. Biochem …

The differences between the redox states of the NAD-and NADP-couples in the cytoplasm
have been measured. The ratio [free NADP]/[free NADPH 2] was found to be about 100,000 …