Recent strategies to develop innovative photosensitizers for enhanced photodynamic therapy

TC Pham, VN Nguyen, Y Choi, S Lee, J Yoon - Chemical reviews, 2021 - ACS Publications
This review presents a robust strategy to design photosensitizers (PSs) for various species.
Photodynamic therapy (PDT) is a photochemical-based treatment approach that involves the …

Biomedical and biochemical applications of self-assembled metallacycles and metallacages

TR Cook, V Vajpayee, MH Lee, PJ Stang… - Accounts of chemical …, 2013 - ACS Publications
Metal ions and metal complexes with organic molecules are ubiquitous in nature. Bulk metal
ions of Na, K, Mg, and Ca constitute as much as 1% of human body weight. The remaining …

Stimuli-responsive Pd 2 L 4 metallosupramolecular cages: towards targeted cisplatin drug delivery

JEM Lewis, EL Gavey, SA Cameron, JD Crowley - Chemical Science, 2012 - pubs.rsc.org
Metallosupramolecular cages are an emerging, but as of yet relativity unexplored, drug
delivery vector. Herein we show that discrete dipalladium (II) molecular cages of the formula …

[HTML][HTML] Recent developments of supramolecular metal-based structures for applications in cancer therapy and imaging

A Pöthig, A Casini - Theranostics, 2019 - ncbi.nlm.nih.gov
The biomedical application of discrete supramolecular metal-based structures, including
supramolecular coordination complexes (SCCs), is still an emergent field of study. However …

Metal‐coordinated supramolecular self‐assemblies for cancer theranostics

J Xu, J Wang, J Ye, J Jiao, Z Liu, C Zhao… - Advanced …, 2021 - Wiley Online Library
Metal‐coordinated supramolecular nanoassemblies have recently attracted extensive
attention as materials for cancer theranostics. Owing to their unique physicochemical …

Encapsulation of Pt (IV) prodrugs within a Pt (II) cage for drug delivery

YR Zheng, K Suntharalingam, TC Johnstone… - Chemical …, 2015 - pubs.rsc.org
This report presents a novel strategy that facilitates delivery of multiple, specific payloads of
Pt (IV) prodrugs using a well-defined supramolecular system. This delivery system …

Targeting nucleus DNA with a cyclometalated dipyridophenazineruthenium (II) complex

H Huang, P Zhang, B Yu, Y Chen, J Wang… - Journal of Medicinal …, 2014 - ACS Publications
Recently, coordinatively saturated and substitutionally inert Ru (II) complexes have been
investigated as anticancer agents. Herein a cyclometalated Ru (II) complex,[Ru …

Interactions of small molecules with DNA junctions

KT McQuaid, A Pipier, CJ Cardin… - Nucleic Acids …, 2022 - academic.oup.com
The four natural DNA bases (A, T, G and C) associate in base pairs (A= T and G≡ C),
allowing the attached DNA strands to assemble into the canonical double helix of DNA (or …

Mitochondrial‐DNA‐Targeted IrIII‐Containing Metallohelices with Tunable Photodynamic Therapy Efficacy in Cancer Cells

X Li, J Wu, L Wang, C He, L Chen… - Angewandte Chemie …, 2020 - Wiley Online Library
The development of DNA‐targeted photodynamic therapy (PDT) agents for cancer treatment
has drawn substantial attention. Herein, the design and synthesis of dinuclear IrIII …

DNA folds threaten genetic stability and can be leveraged for chemotherapy

J Zell, FR Sperti, S Britton, D Monchaud - RSC Chemical Biology, 2021 - pubs.rsc.org
Damaging DNA is a current and efficient strategy to fight against cancer cell proliferation.
Numerous mechanisms exist to counteract DNA damage, collectively referred to as the DNA …