The 'cytokine storm': molecular mechanisms and therapeutic prospects

R Karki, TD Kanneganti - Trends in immunology, 2021 - cell.com
Cytokine storm syndrome (CSS) has generally been described as a collection of clinical
manifestations resulting from an overactivated immune system. Cytokine storms (CSs) are …

Pharmaco-immunomodulatory therapy in COVID-19

JG Rizk, K Kalantar-Zadeh, MR Mehra, CJ Lavie… - Drugs, 2020 - Springer
The severe acute respiratory syndrome coronavirus 2 associated coronavirus disease 2019
(COVID-19) illness is a syndrome of viral replication in concert with a host inflammatory …

Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed

M Feldmann, RN Maini, JN Woody, ST Holgate… - The Lancet, 2020 - thelancet.com
With more than 81 000 deaths worldwide from coronavirus disease 2019 (COVID-19) by
April 8, 2020, 1 it is incumbent on researchers to accelerate clinical trials of any readily …

Role of inflammatory cytokines in COVID-19 patients: A review on molecular mechanisms, immune functions, immunopathology and immunomodulatory drugs to …

AA Rabaan, SH Al-Ahmed, J Muhammad, A Khan… - Vaccines, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is a severe pandemic of the current century. The vicious …

Targeting TNF-α for COVID-19: recent advanced and controversies

Y Guo, K Hu, Y Li, C Lu, K Ling, C Cai… - Frontiers in public …, 2022 - frontiersin.org
Recent advances in the pathophysiologic understanding of coronavirus disease 2019
(COVID-19) suggests that cytokine release syndrome (CRS) has an association with the …

[HTML][HTML] IL-6: Relevance for immunopathology of SARS-CoV-2

EO Gubernatorova, EA Gorshkova, AI Polinova… - Cytokine & growth factor …, 2020 - Elsevier
COVID-19 mortality is strongly associated with the development of severe pneumonia and
acute respiratory distress syndrome with the worst outcome resulting in cytokine release …

[HTML][HTML] Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression

G Schönrich, MJ Raftery, Y Samstag - Advances in biological regulation, 2020 - Elsevier
Abstract Pandemic coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and poses an unprecedented challenge …

COVID-19 revisiting inflammatory pathways of arthritis

G Schett, B Manger, D Simon, R Caporali - Nature Reviews …, 2020 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease, caused by severe
acute respiratory syndrome coronavirus 2, which predominantly affects the lungs and, under …

The CD8 T cell response to respiratory virus infections

ME Schmidt, SM Varga - Frontiers in immunology, 2018 - frontiersin.org
Humans are highly susceptible to infection with respiratory viruses including respiratory
syncytial virus (RSV), influenza virus, human metapneumovirus, rhinovirus, coronavirus, and …

Diet supplementation, probiotics, and nutraceuticals in SARS-CoV-2 infection: a scoping review

F Infusino, M Marazzato, M Mancone, F Fedele… - Nutrients, 2020 - mdpi.com
The severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) global pandemic is a
devastating event that is causing thousands of victims every day around the world. One of …