The bioavailability of members of the transforming growth factor β (TGF-β) family is
controlled by a number of mechanisms. Bona fide TGF-β is sequestered into the matrix in a …

Transforming growth factor-β (TGF-β) is a central player in fibrotic disease. Clinical trials with
global inhibitors of TGF-β have been disappointing, suggesting that a more targeted …

The thrombospondin (Thbs) family of secreted matricellular proteins are stress-and injury-
induced mediators of cellular attachment dynamics and extracellular matrix protein …

We have uncovered a novel functional relationship between the hyaluronan receptor CD44,
the matrix metalloproteinase-9 (MMP-9) and the multifunctional cytokine TGF-β in the control …

We undertook a systematic study focused on the matricellular protein Thrombospondin-1
(THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma …

The activity of TGF-β1 is regulated primarily extracellularly where the secreted latent form
must be modified to expose the active molecule. Here we show that thrombospondin-1 is …

Members of the TGF-β superfamily, which includes TGF-βs, growth differentiation factors,
bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic …

Extensive work on the mechanisms of tumor invasion and metastasis has identified matrix
metalloproteinases (MMPs) as key players in the events that underlie tumor dissemination …

The corneal endothelial monolayer helps maintain corneal transparency through its barrier
and ionic “pump” functions. This transparency function can become compromised, resulting …

Regulation of the activation of latent TGF-β is essential for health as too much or too little
TGF-β activity can have serious, deleterious consequences. The processes that control …